Phosphodiesterase 8 governs cAMP/PKA-dependent reduction of L-type calcium current in human atrial fibrillation: a novel arrhythmogenic mechanism.

Nefeli Grammatika PavlidouShokoufeh DobrevKira BenekeFranziska ReinhardtSimon Pecha Eric JacquetIssam H Abu-TahaConstanze Schmidt Niels Voigt Markus KamlerRenate B SchnabelIstvan BaczkoAnne GarnierHermann ReichenspurnerViacheslav O Nikolaev Dobromir Dobrev Cristina E Molina

Published in: European heart journal (2023)

Both PDE8A and PDE8B are expressed in human heart. Upregulation of PDE8B isoforms in cAF reduces ICa,L via direct interaction of PDE8B2 with the Cav1.2α1C subunit. Thus, upregulated PDE8B2 might serve as a novel molecular mechanism of the proarrhythmic reduction of ICa,L in cAF.

Keyphrases

endothelial cells
atrial fibrillation
heart failure
induced pluripotent stem cells
pluripotent stem cells
cell proliferation
poor prognosis
percutaneous coronary intervention
left atrial appendage
venous thromboembolism
left ventricular