Prostate-Specific Membrane Antigen Expression and Response to DNA Damaging Agents in Prostate Cancer.

Beshara SheehanAntje J NeebLorenzo BuroniAlec PaschalisRuth RiisnaesBora Gurel Veronica S Gil Susana Miranda Mateus Crespo Christina GuoJuan Jiménez VacasInes FigueiredoAna FerreiraJon WeltiWei YuanSuzanne CarreiraAdam SharpJohann S de Bono

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

The results presented herein are the first, to our knowledge, to demonstrate that PSMA is upregulated in response to double-strand DNA damage by anticancer treatment. These data support the study of rational combinations that maximize the antitumor activity of PSMA-targeted therapeutic strategies by upregulating PSMA.

Keyphrases

pet ct
prostate cancer
pet imaging
dna damage
radical prostatectomy
healthcare
poor prognosis
oxidative stress
electronic health record
big data
cancer therapy
computed tomography
combination therapy
drug delivery
deep learning