Emulating the GRADE trial using real world data: retrospective comparative effectiveness study.

Yihong DengEric C PolleyJoshua D WallachSanket S DhruvaJeph HerrinKenneth QuintoCharu GandotraWilliam CrownPeter NoseworthyXiaoxi YaoTimothy D LyonNilay D ShahJoseph S RossRozalina Grubina McCoy

Published in: BMJ (Clinical research ed.) (2022)

In this emulation of the GRADE trial, liraglutide was statistically significantly more effective at maintaining glycemic control than glimepiride or sitagliptin when added to metformin monotherapy. Generating timely evidence on medical treatments using real world data as a complement to prospective trials is of value.

Keyphrases

glycemic control
phase iii
type diabetes
study protocol
electronic health record
phase ii
clinical trial
open label
big data
healthcare
blood glucose
randomized controlled trial
cross sectional
combination therapy
insulin resistance
machine learning
deep learning