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Methionine mediates resilience to chronic social defeat stress by epigenetic regulation of NMDA receptor subunit expression.

Maria BilenPascal IbrahimNour BarmoEdwina Abou HaidarNabil KarnibLauretta El HayekMohamad KhalifehVanessa JabreRouba HoubeikaJoseph S StephanSama F Sleiman
Published in: Psychopharmacology (2020)
Our data indicate that Met rescues susceptibility to stress by inactivating cortical NMDAR activity through an epigenetic mechanism involving histone methylation.
Keyphrases
  • dna methylation
  • poor prognosis
  • gene expression
  • genome wide
  • stress induced
  • electronic health record
  • climate change
  • mouse model
  • tyrosine kinase
  • social support
  • big data
  • heat stress
  • machine learning
  • deep learning