Longitudinal Monitoring of ctDNA in Patients with Melanoma and Brain Metastases Treated with Immune Checkpoint Inhibitors.
Jenny H J LeeAlexander M MenziesMatteo S CarlinoAshleigh C McEvoyShahneen SandhuAlison M WepplerRussell J DiefenbachSarah-Jane DawsonRichard F KeffordMichael J MillwardZeyad Al-OgailiThien TraElin Solomonovna GrayStephen Q WongRichard A ScolyerGeorgina V LongHelen RizosPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
ctDNA remains a strong prognostic biomarker in patients with melanoma with brain metastases, especially in patients with concurrent extracranial disease. However, ctDNA was not able to detect or monitor intracranial disease activity, and we recommend against using ctDNA as a sole test during surveillance and therapeutic monitoring in patients with melanoma.