Adverse birth outcomes and early-life infections after in utero exposure to corticosteroids for inflammatory bowel disease: a Danish nationwide cohort study.
Line Riis JølvingJan NielsenMette Louise AndersenSonia FriedmanBente Mertz NørgårdPublished in: BMC medicine (2023)
This nationwide cohort study suggests that children of women with IBD exposed to corticosteroids in utero had an almost 2.5-fold increased risk of preterm birth. Use of corticosteroids is closely related to disease activity and we cannot adjust for the independent role of disease activity. It is however reassuring that the other examined birth and early-life outcomes were not statistically significantly increased.
Keyphrases
- disease activity
- early life
- preterm birth
- systemic lupus erythematosus
- rheumatoid arthritis
- gestational age
- rheumatoid arthritis patients
- ankylosing spondylitis
- juvenile idiopathic arthritis
- low birth weight
- cross sectional
- emergency department
- preterm infants
- skeletal muscle
- type diabetes
- adipose tissue
- pregnant women