Novel microenvironment-based classification of intrahepatic cholangiocarcinoma with therapeutic implications.

Miguel A Martin-SerranoBenjamin KepecsMiguel Torres-MartinEmily R BramelPhilipp K HaberElliot MerrittAlexander RialdiNesteene Joy ParamMiho MaedaKatherine E LindbladJames K CarterMarina Barcena-VarelaVincenzo MazzaferroMyron SchwartzSilvia AffoRobert F SchwabeAugusto VillanuevaErnesto GuccioneScott L Friedman Amaia LujambioAnna TochevaJosep M LlovetSwan N ThungAlexander M TsankovDaniela Sia

Published in: Gut (2022)

We describe a comprehensive TME-based stratification of iCCA. Cross-species analysis establishes murine models that align closely to human iCCA for the preclinical testing of combination strategies.

Keyphrases

endothelial cells
machine learning
stem cells
deep learning
cell therapy
pluripotent stem cells
genetic diversity