Unified Mouse and Human Kidney Single-Cell Expression Atlas Reveal Commonalities and Differences in Disease States.
Jianfu ZhouAmin AbediniMichael S BalzerShreshtha RojeshPoonam DhillonHongbo LiuHailong HuKatalin SusztákPublished in: Journal of the American Society of Nephrology : JASN (2023)
This study provides a comprehensive mouse kidney single-cell atlas and defines gene expression commonalities and differences in disease states in mice. The results highlight the key role of cell heterogeneity in driving changes in bulk gene expression and the limited overlap of single-cell gene expression changes between animal models and patients, but they also reveal consistent pathway-level changes.
Keyphrases
- single cell
- gene expression
- rna seq
- dna methylation
- high throughput
- end stage renal disease
- ejection fraction
- endothelial cells
- newly diagnosed
- poor prognosis
- peritoneal dialysis
- prognostic factors
- stem cells
- patient reported outcomes
- high fat diet induced
- mesenchymal stem cells
- insulin resistance
- adipose tissue
- pluripotent stem cells