Hypoxia-inducible factor 1α promotes interleukin 1β and tumour necrosis factor α expression in lipopolysaccharide-stimulated human dental pulp cells.

M Fujii Nobuyuki Kawashima K Tazawa Kentaro Hashimoto K Nara Sonoko Noda Shigenori Nagai Takashi Okiji

Published in: International endodontic journal (2020)

HIF1α promoted mRNA expression of IL1β and TNFα via NFκB signalling in LPS-stimulated hDPCs, suggesting that HIF1α is involved in the progress of inflammation in dental pulp.

Keyphrases

endothelial cells
induced apoptosis
oxidative stress
lps induced
inflammatory response
signaling pathway
poor prognosis
cell cycle arrest
rheumatoid arthritis
pi k akt
toll like receptor
induced pluripotent stem cells
nuclear factor
anti inflammatory
pluripotent stem cells
long non coding rna
cell proliferation