Prognostic Epstein-Barr Virus (EBV) miRNA biomarkers for survival outcome in EBV-associated epithelial malignancies: Systematic review and meta-analysis.

Mai Abdel Haleem A AbusalahAhmad Adebayo IrekeolaRafidah Hanim ShuebMu'taman Khalil Mohmoud Jarrar Chan Yean Yean

Published in: PloS one (2022)

To the best of our knowledge, this is the first meta-analysis that investigates the significance of EBV miRNAs as prognostic biomarkers in NPC and GC patients. The pooled effect estimates of HR of the various studies revealed that higher EBV miRNA expression in NPC and GC may result in a worse survival outcome. To assess the clinical significance of EBV miRNAs as prognostic biomarkers, larger-scale prospective studies are needed.

Keyphrases

epstein barr virus
diffuse large b cell lymphoma
systematic review
case control
end stage renal disease
healthcare
chronic kidney disease
newly diagnosed
prognostic factors
poor prognosis
randomized controlled trial
free survival
patient reported outcomes
tandem mass spectrometry