Evolutionary Analysis of the Mammalian IL-17 Cytokine Family Suggests Conserved Roles in Female Fertility.

Federica GiangraziDafne BuffaAndrew T LloydAnthony K RedmondLouise E Glover Cliona O'Farrelly

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2024)

The conservation of the IL-17 gene and protein across mammals suggests similar functions in all the analysed species. Despite significant differences, the upregulation of IL-17 expression is associated with the establishment of pregnancy in eutherian and metatherian mammals. The dysregulation of IL-17s in human reproductive disorders suggests them as a potential therapeutic target.

Keyphrases

poor prognosis
endothelial cells
genome wide
gene expression
copy number
dna methylation
amino acid
human health
pluripotent stem cells