Functional homologous recombination assay on FFPE specimens of advanced high-grade serous ovarian cancer predicts clinical outcomes.

Sanna Pikkusaari Manuela Tumiati Anni Virtanen Jaana Oikkonen Yilin Li Fernando Pérez-Villatoro Taru A Muranen Matilda Salko Kaisa Huhtinen Anna Kanerva Heidi Koskela Johanna Tapper Riitta Koivisto-Korander Titta Joutsiniemi Ulla-Maija Haltia Heini Lassus Sampsa Hautaniemi Anniina Farkkila Johanna Hynninen Sakari Hietanen Olli Carpen Liisa Kauppi

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

We developed a functional HR assay performed on routine FFPE specimens, obtained from either chemo-naïve or NACT-treated HGSC patients, that can significantly predict real-world platinum-based chemotherapy and PARPi response.

Keyphrases

high grade
newly diagnosed
end stage renal disease
low grade

dna damage
high throughput
ejection fraction
dna repair

locally advanced
peritoneal dialysis
prognostic factors
photodynamic therapy

clinical practice
drug delivery
patient reported
ultrasound guided