Rickettsia Vaccine Candidate pVAX1-OmpB24 Stimulates TCD4+INF-γ+ and TCD8+INF-γ+ Lymphocytes in Autologous Co-Culture of Human Cells.
Karla Dzul-RosadoLuis Donis-MaturanoJuan Arias-LeónJesús Machado-ContrerasGuillermo Valencia PachecoCandi Panti-BalamJavier Balam-RomeroAngela Ku-GonzálezGaspar Peniche-LaraJuan Joel Mosqueda GualitoOscar E ZazuetaCesar Lugo-CaballeroFernando Puerto-ManzanoPublished in: Vaccines (2023)
the larger number of cells corresponded to TCD4+PD1+. Human macrophages transfected with pVAX1-OmpB24 activated TCD4+IFN-γ+ and CD8+IFN-γ+ in patients infected with different Rickettsia species. However, PD1 expression played an important role in the inhibition of T lymphocytes with
Keyphrases
- end stage renal disease
- ejection fraction
- induced apoptosis
- immune response
- endothelial cells
- chronic kidney disease
- dendritic cells
- newly diagnosed
- poor prognosis
- prognostic factors
- peritoneal dialysis
- cell cycle arrest
- peripheral blood
- bone marrow
- oxidative stress
- induced pluripotent stem cells
- pluripotent stem cells
- nk cells