Early path dominance as a principle for neurodevelopment.
Rostam M RazbanJonathan Asher PachterKen A DillLilianne Rivka Mujica-ParodiPublished in: Proceedings of the National Academy of Sciences of the United States of America (2023)
We perform targeted attack, a systematic computational unlinking of the network, to analyze its effects on global communication across the brain network through its giant cluster. Across diffusion magnetic resonance images from individuals in the UK Biobank, Adolescent Brain Cognitive Development Study and Developing Human Connectome Project, we find that targeted attack procedures on increasing white matter tract lengths and densities are remarkably invariant to aging and disease. Time-reversing the attack computation suggests a mechanism for how brains develop, for which we derive an analytical equation using percolation theory. Based on a close match between theory and experiment, our results demonstrate that tracts are limited to emanate from regions already in the giant cluster and tracts that appear earliest in neurodevelopment are those that become the longest and densest.
Keyphrases
- white matter
- magnetic resonance
- resting state
- multiple sclerosis
- functional connectivity
- endothelial cells
- cancer therapy
- young adults
- mental health
- deep learning
- cross sectional
- machine learning
- mass spectrometry
- convolutional neural network
- optical coherence tomography
- contrast enhanced
- induced pluripotent stem cells
- magnetic resonance imaging
- network analysis
- liquid chromatography