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Safety of dihydroartemisinin-piperaquine versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria among children in Africa: a systematic review and meta-analysis of randomized control trials.

Dawit Getachew AssefaEden Dagnachew ZelekeWondwosen MollaNebiyu MengistuAhmedin SefaAndualem MebratuAsresu Feleke BateEtaferaw BekeleGizachew YesmawEyasu Makonnen
Published in: Malaria journal (2022)
From this review, it can be concluded that early vomiting, diarrhoea, and cough were common were significantly more frequent in patients who were treated with the DHA-PQ than that of AL, and both drugs are well tolerated. More studies comparing AL with DHA-PQ are needed to determine the comparative safety of these drugs.
Keyphrases
  • plasmodium falciparum
  • fatty acid
  • open label
  • double blind
  • phase iii
  • urinary tract infection
  • phase ii
  • randomized controlled trial
  • combination therapy
  • abdominal pain
  • smoking cessation