InterPro in 2017-beyond protein family and domain annotations.
Robert D FinnTeresa K AttwoodPatricia C BabbittAlex BatemanPeer BorkAlan J BridgeHsin-Yu ChangZsuzsanna DosztányiSara El-GebaliMatthew FraserJulian GoughDavid HaftGemma L HollidayHongzhan HuangXiaosong HuangIvica LetunicRodrigo LopezShennan LuAron Marchler-BauerHuaiyu MiJaina MistryDarren A NataleMarco NecciGift NukaChristine A OrengoYoungmi ParkSebastien PesseatDamiano PiovesanSimon C PotterNeil D RawlingsNicole RedaschiLorna RichardsonCatherine RivoireAmaia Sangrador-VegasChristian SigristIan SillitoeBen SmithersSilvano SquizzatoGranger SuttonNarmada ThankiPaul D ThomasSilvio C E TosattoCathy H WuIoannis XenariosLai-Su YehSiew-Yit YoungAlex L MitchellPublished in: Nucleic acids research (2016)
InterPro (http://www.ebi.ac.uk/interpro/) is a freely available database used to classify protein sequences into families and to predict the presence of important domains and sites. InterProScan is the underlying software that allows both protein and nucleic acid sequences to be searched against InterPro's predictive models, which are provided by its member databases. Here, we report recent developments with InterPro and its associated software, including the addition of two new databases (SFLD and CDD), and the functionality to include residue-level annotation and prediction of intrinsic disorder. These developments enrich the annotations provided by InterPro, increase the overall number of residues annotated and allow more specific functional inferences.