The relationship between depression and cognitive function in adults with cardiovascular risk: Evidence from a randomised attention-controlled trial.
Haley M LaMonicaDaniel J BiddleSharon L NaismithIan B HickiePaul MaruffNicholas GlozierPublished in: PloS one (2018)
Adults with comorbid mild-to-moderate depressive symptoms and cardiovascular risks performed less well than age-matched normative data on three online cognitive tests; however, we were unable to show any symptom-cognition association cross-sectionally or longitudinally, despite significant improvements in depressive symptoms. This challenges the generalisability of such associations found in more severely unwell clinical samples to those with a broader depressive symptom profile, or suggests that underlying cardiovascular disease may account for the association seen in some clinical studies. This has implications for scaling up selective prevention of cognitive decline.
Keyphrases
- depressive symptoms
- cognitive decline
- mild cognitive impairment
- cardiovascular disease
- social support
- sleep quality
- open label
- double blind
- clinical trial
- study protocol
- type diabetes
- working memory
- bipolar disorder
- randomized controlled trial
- healthcare
- electronic health record
- big data
- patient reported
- health information
- physical activity
- multiple sclerosis
- risk assessment