Risk-Reducing Gynecological Surgery in Lynch Syndrome: Results of an International Survey from the Prospective Lynch Syndrome Database.
Mev Dominguez-ValentinToni T SeppäläChristoph EngelStefan AretzFinlay MacraeIngrid WinshipGabriel Capellá MunarHuw ThomasEivind HovigMaartje NielsenRolf H SijmonsLucio BertarioBernardo BonanniMaria Grazia TibilettiGiulia Martina CavestroMiriam MintsNathan GluckLior KatzKarl HeinimannCarlos Alberto VaccaroKate GreenFiona LallooJames HillWolff SchmiegelDeepak Ben VangalaClaudia PerneHans-Georg StraußJohanna TecklenburgElke Holinski-FederVerena Steinke-LangeJukka-Pekka MecklinJohn-Paul PlazzerMarta PinedaMatilde NavarroJoan Brunet VidalRevital KarivGuy RosnerTamara Alejandra PiñeroMaría Laura GonzalezPablo KalfayanJulian R SampsonNeil A J RyanD Gareth EvansPål MøllerEmma J CrosbiePublished in: Journal of clinical medicine (2020)
Most centers offer risk-reducing gynecological surgery to carriers of path_MLH1, path_MSH2 and path_MSH6 variants but less so for path_PMS2 carriers. There is wide variation in how, when and to whom this is offered. The Manchester International Consensus Group developed recommendations to harmonize clinical practice across centers, but there is a clear need for more research.