TSPAN4 and migrasomes in atherosclerosis regression correlated to myocardial infarction and pan-cancer progression.
Tong LiYuheng LangBingcai QiTong LiPublished in: Cell adhesion & migration (2022)
The migrasomes formation is mediated by the assembly of micron-scale tetraspanin macrodomains and the recruitment of tetraspanin 4 (TSPAN4). However, the physiological functions of TSPAN4 on migrasomes are less known. The TSPAN4 expression in macrophages in single-cell sequencing data, GEO datasets and TCGA database were determined. TSPAN4 expression was highly associated with atherosclerosis regression-related macrophages, intraplaque hemorrhage and ruptured plaques. TSPAN4 expression was upregulated in spontaneous MI and inducible MI mice model. Besides, TSPAN4 expression was highly correlated with tumor-associated macrophages. The study provided a critical role of TSPAN4 aberrant expression in the progression of atherosclerosis and pan-cancer, and the intervention of TSPAN4 and migrasomes may save dying patients' lives and improve their prognosis.
Keyphrases
- poor prognosis
- single cell
- cardiovascular disease
- binding protein
- long non coding rna
- heart failure
- randomized controlled trial
- papillary thyroid
- rna seq
- emergency department
- ejection fraction
- prognostic factors
- newly diagnosed
- metabolic syndrome
- young adults
- left ventricular
- machine learning
- insulin resistance
- adipose tissue
- big data
- artificial intelligence
- patient reported outcomes