Elucidating the Proximal Tubule HNF4A Gene Regulatory Network in Human Kidney Organoids.

Yasuhiro Yoshimura Yoshiharu Muto Kohei Omachi Jeffery H Miner Benjamin D Humphreys

Published in: Journal of the American Society of Nephrology : JASN (2023)

Our study reveals regulatory mechanisms of HNF4A and HNF4G during human proximal tubule differentiation. The experimental strategy can be applied more broadly to investigate transcriptional regulation in human kidney development.

Keyphrases

endothelial cells
induced pluripotent stem cells
pluripotent stem cells
transcription factor