N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression.

Xinyue Zhang Tianhong Su Yifan Wu Yuhong Cai Lina Wang Cong Liang Lei Zhou Shiyan Wang Xiao-Xing Li Sui Peng Ming Kuang Jun Yu Lixia Xu

Published in: Cancer research (2024)

Inhibition of YTHDF1 expression suppresses stemness of hepatocellular carcinoma cells and enhances sensitivity to targeted therapies, indicating that targeting YTHDF1 may be a promising therapeutic strategy for liver cancer.

Keyphrases

poor prognosis
stem cells
epithelial mesenchymal transition
binding protein
signaling pathway
cell proliferation
long non coding rna
cancer therapy
cancer stem cells
drug delivery