Total Neoadjuvant Therapy (TNT) versus Standard Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer: A Systematic Review and Meta-Analysis.
Shuang LiuTing JiangLin XiaoShanfei YangQing LiuYuanhong GaoGong ChenWei-Wei XiaoPublished in: The oncologist (2021)
Locally advanced rectal cancer (LARC) is a relatively common disease, with a poor prognosis because of its high metastatic potential. The role of total neoadjuvant therapy (TNT) has always been controversial. This meta-analysis found that TNT in LARC is associated with a significant improvement in overall pathologic complete response rate, disease-free survival, overall survival, and distant metastasis-free survival compared with standard treatment. TNT is a promising strategy for LARC, especially for patients who have little desire for surgery.
Keyphrases
- rectal cancer
- free survival
- locally advanced
- poor prognosis
- neoadjuvant chemotherapy
- squamous cell carcinoma
- phase ii study
- systematic review
- long non coding rna
- end stage renal disease
- radiation therapy
- ejection fraction
- small cell lung cancer
- chronic kidney disease
- minimally invasive
- peritoneal dialysis
- lymph node
- prognostic factors
- stem cells
- coronary artery bypass
- randomized controlled trial
- patient reported outcomes
- replacement therapy
- human health
- coronary artery disease