Immunotherapy-Mediated Thyroid Dysfunction: Genetic Risk and Impact on Outcomes with PD-1 Blockade in Non-Small Cell Lung Cancer.

Jia LuoVictoria L MartucciZoe QuandtStefan GrohaMegan H MurrayChristine M LovlyHira RizviJacklynn V Egger Andrew J PlodkowskiMohsen Abu-AkeelIsabell SchulzeTaha Merghoub Eduardo CardenasScott HuntsmanMin LiDonglei HuMatthew A GubensAlexander GusevMelinda C Aldrich Matthew D Hellmann Elad Ziv

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Thyroid irAEs were associated with response to anti-PD-1 therapy. Genetic risk for hypothyroidism was associated with risk of developing thyroid irAEs. Additional studies are needed to determine whether other irAEs also have shared genetic risk with known autoimmune disorders and the association with treatment response.

Keyphrases

genome wide
copy number
multiple sclerosis
stem cells
metabolic syndrome
adipose tissue
dna methylation
weight loss
skeletal muscle
drug induced