Taha Merghoub

Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 47

Top Topics

Tyrosine Kinase

Regulatory T Cells

Peripheral Blood

Immune Response

Top Venues

Clinical cancer research : an official journal of the American Association for Cancer Research

The Journal of experimental medicine

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Anton Dobrin, Pieter L Lindenbergh, Yuzhe Shi, Karlo Perica, Hongyao Xie, Nayan Jain, Andrew Chow, Jedd D Wolchok, Taha Merghoub, Michel Sadelain, Mohamad Hamieh
Synthetic dual co-stimulation increases the potency of HIT and TCR-targeted cell therapies. Nature cancer 5 (5) (2024)
Anton Dobrin, Pieter L Lindenbergh, Yuzhe Shi, Karlo Perica, Hongyao Xie, Nayan Jain, Andrew Chow, Jedd D Wolchok, Taha Merghoub, Michel Sadelain, Mohamad Hamieh
Synthetic dual co-stimulation increases the potency of HIT and TCR-targeted cell therapies. Nature cancer (2024)
Mario E Lacouture, Elena Goleva, Neil J Shah, Veronica M Rotemberg, Lukas Kraehenbuehl, Kwami F Ketosugbo, Taha Merghoub, Tara Maier, Alexander Sydat Bang, Stephanie Gu, Trina Salvador, Andrea P Moy, Taras Lyubchenko, Olivia Xiao, Clifton F Hall, Evgeny V Berdyshev, James L Crooks, Ryan Weight, Jeffrey A Kern, Donald Y M Leung
Immunologic Profiling of Immune-Related Cutaneous Adverse Events with Checkpoint Inhibitors Reveals Polarized Actionable Pathways. Clinical cancer research : an official journal of the American Association for Cancer Research 30 (13) (2024)
Anton Dobrin, Pieter L Lindenbergh, Yuzhe Shi, Karlo Perica, Hongyao Xie, Nayan Jain, Andrew Chow, Jedd D Wolchok, Taha Merghoub, Michel Sadelain, Mohamad Hamieh
Synthetic dual co-stimulation increases the potency of HIT and TCR-targeted cell therapies. Nature cancer 5 (5) (2024)
Mario E Lacouture, Elena Goleva, Neil J Shah, Veronica M Rotemberg, Lukas Kraehenbuehl, Kwami F Ketosugbo, Taha Merghoub, Tara Maier, Alexander Sydat Bang, Stephanie Gu, Trina Salvador, Andrea P Moy, Taras Lyubchenko, Olivia Xiao, Clifton F Hall, Evgeny V Berdyshev, James L Crooks, Ryan Weight, Jeffrey A Kern, Donald Y M Leung
Immunologic Profiling of Immune-Related Cutaneous Adverse Events with Checkpoint Inhibitors Reveals Polarized Actionable Pathways. Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Mario E Lacouture, Elena Goleva, Neil J Shah, Veronica M Rotemberg, Lukas Kraehenbuehl, Kwami F Ketosugbo, Taha Merghoub, Tara Maier, Alexander Sydat Bang, Stephanie Gu, Trina Salvador, Andrea P Moy, Taras Lyubchenko, Olivia Xiao, Clifton F Hall, Evgeny V Berdyshev, James L Crooks, Ryan Weight, Jeffrey A Kern, Donald Y M Leung
Immunologic Profiling of Immune-Related Cutaneous Adverse Events with Checkpoint Inhibitors Reveals Polarized Actionable Pathways. Clinical cancer research : an official journal of the American Association for Cancer Research 30 (13) (2024)
Lauren Dong, Hyejin Choi, Sadna Budhu, Isabell Schulze, Svena Verma, Levi Mark Mangarin, Valeria Estrada Navarro, Nezar Mehanna, Jonathan F Khan, Divya Venkatesh, Daniel Thach, Neal X Rosen, Jedd D Wolchok, Taha Merghoub
Intermittent MEK inhibition with GITR co-stimulation rescues T-cell function for increased efficacy with CTLA-4 blockade in solid tumor models. Cancer immunology research (2024)
Mario E Lacouture, Elena Goleva, Neil J Shah, Veronica M Rotemberg, Lukas Kraehenbuehl, Kwami F Ketosugbo, Taha Merghoub, Tara Maier, Alexander Sydat Bang, Stephanie Gu, Trina Salvador, Andrea P Moy, Taras Lyubchenko, Olivia Xiao, Clifton F Hall, Evgeny V Berdyshev, James L Crooks, Ryan Weight, Jeffrey A Kern, Donald Y M Leung
Immunologic Profiling of Immune-Related Cutaneous Adverse Events with Checkpoint Inhibitors Reveals Polarized Actionable Pathways. Clinical cancer research : an official journal of the American Association for Cancer Research 30 (13) (2024)
Anton Dobrin, Pieter L Lindenbergh, Yuzhe Shi, Karlo Perica, Hongyao Xie, Nayan Jain, Andrew Chow, Jedd D Wolchok, Taha Merghoub, Michel Sadelain, Mohamad Hamieh
Synthetic dual co-stimulation increases the potency of HIT and TCR-targeted cell therapies. Nature cancer (2024)
Luis A Rojas, Zachary Sethna, Kevin C Soares, Cristina Olcese, Nan Pang, Erin Patterson, Jayon Lihm, Nicholas Ceglia, Pablo Guasp, Alexander Chu, Rebecca Yu, Adrienne Kaya Chandra, Theresa Waters, Jennifer Ruan, Masataka Amisaki, Abderezak Zebboudj, Zagaa Odgerel, George Payne, Evelyna Derhovanessian, Felicitas Müller, Ina Rhee, Mahesh Yadav, Anton Dobrin, Michel Sadelain, Marta Łuksza, Noah A Cohen, Laura Tang, Olca Basturk, Mithat Gönen, Seth Katz, Richard Kinh Do, Andrew S Epstein, Parisa Momtaz, Wungki Park, Ryan Sugarman, Anna M Varghese, Elizabeth Won, Avni Desai, Alice C Wei, Michael I D'Angelica, T Peter Kingham, Ira Mellman, Taha Merghoub, Jedd D Wolchok, Uğur Şahin, Özlem Türeci, Benjamin D Greenbaum, William R Jarnagin, Jeffrey Drebin, Eileen M O'Reilly, Vinod P Balachandran
Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer. Nature (2023)
Divya Venkatesh, Taha Merghoub
Paving the Way for Cancer Therapy a Nano Step at a Time. The Journal of pharmacology and experimental therapeutics 384 (3) (2023)
Luis A Rojas, Zachary Sethna, Kevin C Soares, Cristina Olcese, Nan Pang, Erin Patterson, Jayon Lihm, Nicholas Ceglia, Pablo Guasp, Alexander Chu, Rebecca Yu, Adrienne Kaya Chandra, Theresa Waters, Jennifer Ruan, Masataka Amisaki, Abderezak Zebboudj, Zagaa Odgerel, George Payne, Evelyna Derhovanessian, Felicitas Müller, Ina Rhee, Mahesh Yadav, Anton Dobrin, Michel Sadelain, Marta Łuksza, Noah A Cohen, Laura Tang, Olca Basturk, Mithat Gönen, Seth Katz, Richard Kinh Do, Andrew S Epstein, Parisa Momtaz, Wungki Park, Ryan Sugarman, Anna M Varghese, Elizabeth Won, Avni Desai, Alice C Wei, Michael I D'Angelica, T Peter Kingham, Ira Mellman, Taha Merghoub, Jedd D Wolchok, Uğur Şahin, Özlem Türeci, Benjamin D Greenbaum, William R Jarnagin, Jeffrey Drebin, Eileen M O'Reilly, Vinod P Balachandran
Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer. Nature (2023)
Ning Yang, Yi Wang, Shuaitong Liu, Shanza Baseer Tariq, Joseph M Luna, Gregory Mazo, Adrian Tan, Tuo Zhang, Jiahu Wang, Wei Yan, John Choi, Anthony Mario Rossi, Jenny Zhaoying Xiang, Charles M Rice, Taha Merghoub, Jedd D Wolchok, Liang Deng
OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs. The Journal of experimental medicine 220 (8) (2023)
Ning Yang, Yi Wang, Shuaitong Liu, Shanza Baseer Tariq, Joseph M Luna, Gregory Mazo, Adrian Tan, Tuo Zhang, Jiahu Wang, Wei Yan, John Choi, Anthony Mario Rossi, Jenny Zhaoying Xiang, Charles M Rice, Taha Merghoub, Jedd D Wolchok, Liang Deng
OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs. The Journal of experimental medicine 220 (8) (2023)
Steven B Maron, Walid K Chatila, Henry S Walch, Joanne F Chou, Nicholas Ceglia, Ryan N Ptashkin, Richard Kinh Gian Do, Viktoriya Paroder, Neeta Pandit-Taskar, Jason S Lewis, Tiago Biachi de Castria, Shalom Sabwa, Fiona Socolow, Lara Feder, Jasmine Thomas, Isabell Schulze, Kwanghee Kim, Arijh Elzein, Viktoria Bojilova, Matthew Zatzman, Umeshkumar K Bhanot, Rebecca J Nagy, Jeeyun Lee, Marc Simmons, Michal Segal, Geoffrey Y Ku, David H Ilson, Marinela Capanu, Jaclyn Frances Hechtman, Taha Merghoub, Sohrab P Shah, Nikolaus Schultz, David B Solit, Yelena Y Janjigian
Determinants of survival in HER2+ metastatic esophagogastric cancer. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Paul B Chapman, Mark G Klang, Michael A Postow, Alexander N Shoushtari, Ryan J Sullivan, Jedd D Wolchok, Taha Merghoub, Sadna Budhu, Phillip Wong, Margaret K Callahan, Bin Zheng, Jonathan H Zippin
Phase Ib trial of phenformin in patients with V600-mutated melanoma receiving dabrafenib and trametinib. Cancer research communications (2023)
Divya Venkatesh, Taha Merghoub
Paving the Way for Cancer Therapy a Nano Step at a Time. The Journal of pharmacology and experimental therapeutics 384 (3) (2023)
Ning Yang, Yi Wang, Shuaitong Liu, Shanza Baseer Tariq, Joseph M Luna, Gregory Mazo, Adrian Tan, Tuo Zhang, Jiahu Wang, Wei Yan, John Choi, Anthony Mario Rossi, Jenny Zhaoying Xiang, Charles M Rice, Taha Merghoub, Jedd D Wolchok, Liang Deng
OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs. The Journal of experimental medicine 220 (8) (2023)
Ning Yang, Yi Wang, Shuaitong Liu, Shanza Baseer Tariq, Joseph M Luna, Gregory Mazo, Adrian Tan, Tuo Zhang, Jiahu Wang, Wei Yan, John Choi, Anthony Mario Rossi, Jenny Zhaoying Xiang, Charles M Rice, Taha Merghoub, Jedd D Wolchok, Liang Deng
OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs. The Journal of experimental medicine 220 (8) (2023)
Ning Yang, Yi Wang, Shuaitong Liu, Shanza Baseer Tariq, Joseph M Luna, Gregory Mazo, Adrian Tan, Tuo Zhang, Jiahu Wang, Wei Yan, John Choi, Anthony Mario Rossi, Jenny Zhaoying Xiang, Charles M Rice, Taha Merghoub, Jedd D Wolchok, Liang Deng
OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs. The Journal of experimental medicine 220 (8) (2023)
Judith Michels, Divya Venkatesh, Cailian Liu, Sadna Budhu, Hong Zhong, Mariam M George, Daniel Thach, Zhong-Ke Yao, Ouathek Ouerfelli, Hengrui Liu, Brent R Stockwell, Luis Felipe Campesato, Dmitriy Zamarin, Roberta Zappasodi, Jedd D Wolchok, Taha Merghoub
APR-246 increases tumor antigenicity independent of p53. Life science alliance 7 (1) (2023)
Mathieu Gigoux, Morten Orebo Holmström, Roberta Zappasodi, Joseph J Park, Stephane Pourpe, Cansu Cimen Bozkus, Levi Mark Mangarin, David Redmond, Svena Verma, Sara Schad, Mariam M George, Divya Venkatesh, Arnab Ghosh, David Hoyos, Zaki Molvi, Baransel Kamaz, Anna E Marneth, William Duke, Matthew Joseph Leventhal, Max Jan, Vincent T Ho, Gabriela S Hobbs, Trine Alma Knudsen, Vibe Skov, Lasse Kjær, Thomas Stauffer Larsen, Dennis Lund Hansen, R Coleman Lindsley, Hans Carl Carl Hasselbalch, Jacob H Grauslund, Thomas L Lisle, Özcan Met, Patrick Wilkinson, Benjamin Greenbaum, Manuel A Sepulveda, Timothy A Chan, Raajit Rampal, Mads Hald Andersen, Omar Abdel-Wahab, Nina Bhardwaj, Jedd D Wolchok, Ann Mullally, Taha Merghoub
Calreticulin mutant myeloproliferative neoplasms induce MHC-I skewing, which can be overcome by an optimized peptide cancer vaccine. Science translational medicine 14 (649) (2022)
Jeppe Sejerø Holm, Samuel A Funt, Annie Borch, Kamilla Kjærgaard Munk, Anne-Mette Bjerregaard, James L Reading, Colleen A Maher, Ashley M Regazzi, Phillip Wong, Hikmat A Al-Ahmadie, Gopakumar V Iyer, Tripti Tamhane, Amalie Kai Bentzen, Nana Overgaard Herschend, Susan De Wolf, Alexandra Snyder, Taha Merghoub, Jedd D Wolchok, Morten Nielsen, Jonathan E Rosenberg, Dean F Bajorin, Sine Reker Hadrup
Neoantigen-specific CD8 T cell responses in the peripheral blood following PD-L1 blockade might predict therapy outcome in metastatic urothelial carcinoma. Nature communications 13 (1) (2022)
Joshua M Weiss, Miranda V Hunter, Nelly M Cruz, Arianna Baggiolini, Mohita M Tagore, Yilun Ma, Sandra Misale, Michelangelo Marasco, Theresa Simon-Vermot, Nathaniel R Campbell, Felicity Newell, James S Wilmott, Peter A Johansson, John F Thompson, Georgina V Long, John V Pearson, Graham J Mann, Richard A Scolyer, Nicola Waddell, Emily D Montal, Ting-Hsiang Huang, Philip Jonsson, Mark T A Donoghue, Christopher C Harris, Barry S Taylor, Tianhao Xu, Ronan Chaligné, Pavel V Shliaha, Ronald Hendrickson, Achim A Jungbluth, Cecilia Lezcano, Richard P Koche, Lorenz Studer, Charlotte E Ariyan, David B Solit, Jedd D Wolchok, Taha Merghoub, Neal X Rosen, Nicholas K Hayward, Richard M White
Anatomic position determines oncogenic specificity in melanoma. Nature 604 (7905) (2022)
Aditi Sahu, Kivanc Kose, Lukas Kraehenbuehl, Candice Byers, Aliya Holland, Teguru Tembo, Anthony Santella, Anabel Alfonso, Madison Li, Miguel Cordova, Melissa Gill, Christi Fox, Salvador Gonzalez, Piyush Kumar, Amber Weiching Wang, Nicholas R Kurtansky, Pratik Chandrani, Shen Yin, Paras Mehta, Cristian Navarrete-Dechent, Gary Peterson, Kimeil King, Stephen W Dusza, Ning Yang, Shuaitong Liu, William Phillips, Pascale Guitera, Anthony Rossi, Allan Halpern, Liang Deng, Melissa Pulitzer, Ashfaq Marghoob, Chih-Shan Jason Chen, Taha Merghoub, Milind Rajadhyaksha
In vivo tumor immune microenvironment phenotypes correlate with inflammation and vasculature to predict immunotherapy response. Nature communications 13 (1) (2022)
Sara E Schad, Andrew Chow, Levi Mark Mangarin, Heng Pan, Jiajia Zhang, Nicholas Ceglia, Justina X Caushi, Nicole Malandro, Roberta Zappasodi, Mathieu Gigoux, Daniel Hirschhorn, Sadna Budhu, Masataka Amisaki, Monica B Arniella, David Redmond, Jamie E Chaft, Patrick M Forde, Justin F Gainor, Matthew D Hellmann, Vinod P Balachandran, Sohrab P Shah, Kellie N Smit, Drew M Pardoll, Olivier Elemento, Jedd D Wolchok, Taha Merghoub
Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions. The Journal of experimental medicine 219 (6) (2022)
Abdel Razaq Ahmad A Alyasin, Borko Amulic, Monowar Aziz, Betsy J Barnes, Evgeniy B Eruslanov, Zvi G Fridlender, Helen S Goodridge, Zvi Granot, Andrés Hidalgo, Anna Huttenlocher, Mariana J Kaplan, Ilaria Malanchi, Taha Merghoub, Etienne Meylan, Vivek Mittal, Mikaël J Pittet, Andrea Rubio-Ponce, Irina A Udalova, Timo K van den Berg, Denisa D Wagner, Ping Wang, Arturo Zychlinsky, Karin E de Visser, Mikala Egeblad, Paul Kubes
Neutrophil phenotypes and functions in cancer: A consensus statement. The Journal of experimental medicine 219 (6) (2022)
Diwakar Davar, Roberta Zappasodi, Hong Wang, Girish S Naik, Takami Sato, Todd Bauer, David L Bajor, Olivier Rixe, Walter Newman, Jingjing Qi, Aliya Holland, Phillip Wong, Lianna Sifferlen, Diane Piper, Cynthia A Sirard, Taha Merghoub, Jedd D Wolchok, Jason John Luke
Phase IB Study of GITR Agonist Antibody TRX518 Singly and in Combination with Gemcitabine, Pembrolizumab, or Nivolumab in Patients with Advanced Solid Tumors. Clinical cancer research : an official journal of the American Association for Cancer Research 28 (18) (2022)
Changhao He, Rachana R Maniyar, Yahel Avraham, Roberta Zappasodi, Radda Rusinova, Walter Newman, Heidi Heath, Jedd D Wolchok, Rony Dahan, Taha Merghoub, Joel R Meyerson
Therapeutic antibody activation of the glucocorticoid-induced TNF receptor by a clustering mechanism. Science advances 8 (8) (2022)
David Hoyos, Roberta Zappasodi, Isabell Schulze, Zachary Sethna, Kelvin César de Andrade, Dean F Bajorin, Chaitanya Bandlamudi, Margaret K Callahan, Samuel A Funt, Sine Reker Hadrup, Jeppe S Holm, Jonathan E Rosenberg, Sohrab P Shah, Ignacio Vàzquez-García, Jorge S Reis-Filho, Michelle Wu, Dmitriy Zamarin, Laura F Campitelli, Edward J Osborne, Mark Klinger, Harlan S Robins, Payal P Khincha, Sharon A Savage, Vinod P Balachandran, Jedd D Wolchok, Matthew D Hellmann, Taha Merghoub, Arnold J Levine, Marta Łuksza, Benjamin D Greenbaum
Fundamental immune-oncogenicity trade-offs define driver mutation fitness. Nature 606 (7912) (2022)
Marta Łuksza, Zachary M Sethna, Luis A Rojas, Jayon Lihm, Barbara Bravi, Yuval Elhanati, Kevin C Soares, Masataka Amisaki, Anton Dobrin, David Hoyos, Pablo Guasp, Abderezak Zebboudj, Rebecca Yu, Adrienne Kaya Chandra, Theresa Waters, Zagaa Odgerel, Joanne Leung, Rajya Kappagantula, Alvin P Makohon-Moore, Amber Johns, Anthony Gill, Mathieu Gigoux, Jedd D Wolchok, Taha Merghoub, Michel Sadelain, Erin Patterson, Remi Monasson, Thierry Mora, Aleksandra M Walczak, Simona Cocco, Christine A Iacobuzio-Donahue, Benjamin D Greenbaum, Vinod P Balachandran
Neoantigen quality predicts immunoediting in survivors of pancreatic cancer. Nature 606 (7913) (2022)
David B Page, Kathryn Beal, Stefanie N Linch, Kateri J Spinelli, Micaela Rodine, Darragh Halpenny, Shanu Modi, Sujata Patil, Robert J Young, Thomas Kaley, Taha Merghoub, David Redmond, Phillip Wong, Christopher A Barker, Adi Diab, Larry Norton, Heather L McArthur
Brain radiotherapy, tremelimumab-mediated CTLA-4-directed blockade +/- trastuzumab in patients with breast cancer brain metastases. NPJ breast cancer 8 (1) (2022)
Aditi Gupta, Sadna Budhu, Kelly Fitzgerald, Rachel Giese, Adam O Michel, Aliya Holland, Luis Felipe Campesato, Jacques van Snick, Catherine Uyttenhove, Gerd Ritter, Jedd D Wolchok, Taha Merghoub
Isoform specific anti-TGFβ therapy enhances antitumor efficacy in mouse models of cancer. Communications biology 4 (1) (2021)
Jia Luo, Victoria L Martucci, Zoe Quandt, Stefan Groha, Megan H Murray, Christine M Lovly, Hira Rizvi, Jacklynn V Egger, Andrew J Plodkowski, Mohsen Abu-Akeel, Isabell Schulze, Taha Merghoub, Eduardo Cardenas, Scott Huntsman, Min Li, Donglei Hu, Matthew A Gubens, Alexander Gusev, Melinda C Aldrich, Matthew D Hellmann, Elad Ziv
Immunotherapy-Mediated Thyroid Dysfunction: Genetic Risk and Impact on Outcomes with PD-1 Blockade in Non-Small Cell Lung Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (18) (2021)
Neil H Segal, Andrea Cercek, Geoffrey Y Ku, Abraham Jing-Ching Wu, Andreas Rimner, Danny N Khalil, Diane Reidy-Lagunes, John Cuaron, T Jonathan Yang, Martin R Weiser, Paul B Romesser, Zsofia K Stadler, Marjorie G Zauderer, Karuna Ganesh, Rona Yaeger, Louise C Connell, David M Faleck, Ghassan K Abou-Alfa, Kathleen C Mcauliffe, Pamela Vaiskauskas, Mark L Solter, Martinique Ogle, Matthew J Adamow, Aliya Holland, Pallavi Vedantam, Phillip Wong, Taha Merghoub, Efsevia Vakiani, Travis J Hollmann, Krishna Juluru, Joanne F Chou, Marinela Capanu, Joseph Erinjeri, Stephen Solomon, Yoshiya Yamada, Nancy Kemeny, Christopher H Crane, Leonard B Saltz
Phase II Single-arm Study of Durvalumab and Tremelimumab with Concurrent Radiotherapy in Patients with Mismatch Repair-proficient Metastatic Colorectal Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (8) (2021)
Roberta Zappasodi, Inna Serganova, Ivan J Cohen, Masatomo Maeda, Masahiro Shindo, Yasin Senbabaoglu, McLane J Watson, Avigdor Leftin, Rachana Maniyar, Svena Verma, Matthew Lubin, Myat Ko, Mayuresh M Mane, Hong Zhong, Cailian Liu, Arnab Ghosh, Mohsen Abu-Akeel, Ellen Ackerstaff, Jason A Koutcher, Ping-Chih Ho, Greg M Delgoffe, Ronald Blasberg, Jedd D Wolchok, Taha Merghoub
CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours. Nature 591 (7851) (2021)
Justina X Caushi, Jiajia Zhang, Zhicheng Ji, Ajay Vaghasia, Boyang Zhang, Emily Han-Chung Hsiue, Brian J Mog, Wenpin Hou, Sune Justesen, Richard Blosser, Ada Tam, Valsamo Anagnostou, Tricia R Cottrell, Haidan Guo, Hok Yee Chan, Dipika Singh, Sampriti Thapa, Arbor G Dykema, Poromendro Burman, Begum Choudhury, Luis Aparicio, Laurene S Cheung, Mara Lanis, Zineb Belcaid, Margueritta El Asmar, Peter B Illei, Rulin Wang, Jennifer Meyers, Kornel Schuebel, Anuj Gupta, Alyza Skaist, Sarah J Wheelan, Jarushka Naidoo, Kristen A Marrone, Malcolm Brock, Jinny Ha, Errol L Bush, Bernard J Park, Matthew Bott, David R Jones, Joshua E Reuss, Victor E Velculescu, Jamie E Chaft, Kenneth W Kinzler, Shibin Zhou, Bert Vogelstein, Janis M Taube, Matthew D Hellmann, Julie R Brahmer, Taha Merghoub, Patrick M Forde, Srinivasan Yegnasubramanian, Hongkai Ji, Drew M Pardoll, Kellie N Smit
Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers. Nature 596 (7870) (2021)
Ronglai Shen, Michael A Postow, Matthew J Adamow, Arshi Arora, Margaret Hannum, Colleen Maher, Phillip Wong, Michael A Curran, Travis J Hollman, Liwei Jia, Hikmat A Al-Ahmadie, Niamh M Keegan, Samuel A Funt, Gopa Iyer, Jonathan E Rosenberg, Dean F Bajorin, Paul B Chapman, Alexander N Shoushtari, Allison Betof Warner, Parisa Momtaz, Taha Merghoub, Jedd D Wolchok, Katherine S Panageas, Margaret K Callahan
LAG-3 expression on peripheral blood cells identifies patients with poorer outcomes after immune checkpoint blockade. Science translational medicine 13 (608) (2021)
Lukas Kraehenbuehl, Chien-Huan Weng, Shabnam Eghbali, Jedd D Wolchok, Taha Merghoub
Enhancing immunotherapy in cancer by targeting emerging immunomodulatory pathways. Nature reviews. Clinical oncology (2021)
Luis Felipe Campesato, Sadna Budhu, Jeremy Tchaicha, Chien-Huan Weng, Mathieu Gigoux, Ivan Jose Cohen, David Redmond, Levi Mangarin, Stephane Pourpe, Cailian Liu, Roberta Zappasodi, Dmitriy Zamarin, Jill Cavanaugh, Alfredo C Castro, Mark G Manfredi, Karen McGovern, Taha Merghoub, Jedd D Wolchok
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine. Nature communications 11 (1) (2020)
Haiping Wang, Fabien Franco, Yao-Chen Tsui, Xin Xie, Marcel Philipp Trefny, Roberta Zappasodi, Syed Raza Mohmood, Juan Fernández-García, Chin-Hsien Tsai, Isabell Schulze, Florence Picard, Etienne Meylan, Roy Silverstein, Ira Goldberg, Sarah-Maria Fendt, Jedd D Wolchok, Taha Merghoub, Camilla Jandus, Alfred Zippelius, Ping-Chih Ho
CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors. Nature immunology 21 (3) (2020)
Jun Li, Mercedes A Duran, Ninjit Dhanota, Walid K Chatila, Sarah E Bettigole, John Kwon, Roshan K Sriram, Matthew Phillip Humphries, Manuel Salto-Tellez, Jacqueline A James, Matthew G Hanna, Johannes C Melms, Sreeram Vallabhaneni, Kevin Litchfield, Ieva Usaite, Dhruva Biswas, Rohan Bareja, Hao Wei Li, Maria Laura Martin, Princesca Dorsaint, Julie-Ann Cavallo, Peng Li, Chantal Pauli, Lee Gottesdiener, Benjamin J DiPardo, Travis J Hollmann, Taha Merghoub, Hannah Y Wen, Jorge S Reis-Filho, Nadeem Riaz, Shin-San Michael Su, Anusha Kalbasi, Neil Vasan, Simon N Powell, Jedd D Wolchok, Olivier Elemento, Charles Swanton, Alexander N Shoushtari, Eileen E Parkes, Benjamin Izar, Samuel F Bakhoum
Metastasis and Immune Evasion from Extracellular cGAMP Hydrolysis. Cancer discovery 11 (5) (2020)
Roberta Zappasodi, Cynthia Sirard, Yanyun Li, Sadna Budhu, Mohsen Abu-Akeel, Cailian Liu, Xia Yang, Hong Zhong, Walter Newman, Jingjing Qi, Phillip Wong, David Schaer, Henry Koon, Vamsidhar Velcheti, Matthew D Hellmann, Michael A Postow, Margaret K Callahan, Jedd D Wolchok, Taha Merghoub
Rational design of anti-GITR-based combination immunotherapy. Nature medicine 25 (5) (2019)
Vivek Verma, Rajeev K Shrimali, Shamim Ahmad, Winjie Dai, Hua Wang, Sumin Lu, Rahul Nandre, Pankaj Gaur, Jose Lopez, Moshe Sade-Feldman, Keren Yizhak, Stacey L Bjorgaard, Keith T Flaherty, Jennifer A Wargo, Genevieve M Boland, Ryan J Sullivan, Gad A Getz, Scott A Hammond, Ming Tan, Jingjing Qi, Phillip Wong, Taha Merghoub, Jedd D Wolchok, Nir Hacohen, John E Janik, Mikayel Mkrtichyan, Seema Gupta, Samir N Khleif
PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance. Nature immunology 20 (9) (2019)
Sadna Budhu, David A Schaer, Yongbiao Li, Ricardo Toledo-Crow, Katherine Panageas, Xia Yang, Hong Zhong, Alan N Houghton, Samuel C Silverstein, Taha Merghoub, Jedd D Wolchok
Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment. Science signaling 10 (494) (2017)
Dmitriy Zamarin, Rikke B Holmgaard, Jacob Ricca, Tamar Plitt, Peter Palese, Padmanee Sharma, Taha Merghoub, Jedd D Wolchok, James P Allison
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity. Nature communications 8 (2017)
Alexandra Snyder, Tavi Nathanson, Samuel A Funt, Arun Ahuja, Jacqueline Buros, Matthew D Hellmann, Eliza Chang, Bülent Arman Aksoy, Hikmat Al-Ahmadie, Erik Yusko, Marissa Vignali, Sharon Benzeno, Mariel Boyd, Meredith Moran, Gopa Iyer, Harlan S Robins, Elaine R Mardis, Taha Merghoub, Jeff Hammerbacher, Jonathan E Rosenberg, Dean F Bajorin
Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: An exploratory multi-omic analysis. PLoS medicine 14 (5) (2017)