Human Heart Failure Alters Mitochondria and Fiber 3D Structure Triggering Metabolic Shifts.
Zer VuePeter T AjayiKit NeikirkAlexandria C MurphyPraveena PrasadBrenita C JenkinsLarry VangEdgar Garza-LopezMargaret MungaiAndrea G MarshallHeather K BeasleyMason KillionRemi ParkerJosephs AnukodemKory LavineOlujimi AjijolaBret C MobleyDao-Fu DaiVernat ExilAnnet KiraboYan Ru SuKelsey TomasekXiuqi ZhangCelestine WanjallaDavid L HubertMark A PhillipsMelanie R McReynoldsBrian GlancyAntentor O HintonPublished in: bioRxiv : the preprint server for biology (2023)
This study, utilizing SBF-SEM, reveals structural alterations in mitochondria and myofibrils in human heart failure (HF). Mitochondria in HF show changes in structure, while myofibrils exhibit increased cross-sectional area and branching. Metabolomic and lipidomic analyses indicate concomitant dysregulation in key pathways. The findings underscore the need for personalized treatments considering individualized structural changes in HF.