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Role of neoadjuvant chemoradiotherapy in liver transplantation for unresectable perihilar cholangiocarcinoma: multicentre, retrospective cohort study.

Frederik J H HoogwaterHendrien KuipersVincent E De MeijerCharlotte MaulatFabrice MuscariWojciech Grzegorz PolakBart van HoekCaroline JézéquelIan P J AlwaynJan N M IjzermansKayvan MohkamJean-Yves MabrutFrederike G I Van VilsterenJean-Philippe AdamLaurence ChicheAlexandre ChebaroEmmanuel BoleslawskiJeroen DubbeldSarwa Darwish MuradMichel RayarRobert J Porte
Published in: BJS open (2023)
In selected patients undergoing liver transplantation for perihilar cholangiocarcinoma, neoadjuvant chemoradiotherapy resulted in a lower risk of tumour recurrence, but was associated with a higher rate of early hepatic vascular complications. Adjustments in neoadjuvant chemoradiotherapy reducing the risk of hepatic vascular complications, such as omitting radiotherapy, may further improve the outcome in patients undergoing liver transplantation for perihilar cholangiocarcinoma.
Keyphrases
  • locally advanced
  • rectal cancer
  • patients undergoing
  • squamous cell carcinoma
  • radiation therapy
  • risk factors
  • clinical trial
  • randomized controlled trial
  • study protocol
  • cross sectional
  • lymph node