Targeting Cyclophilin A in the Cardiac Microenvironment Preserves Heart Function and Structure in Failing Hearts.
Manuel SigleAnne-Katrin RohlfingMelanie Cruz SantosTimo KoppKonstantin KrutzkeVincent GidlundFerdinand KollotzekJulia MarziSaskia von Ungern-SternbergAntti PosoMathias HeikenwälderKatja Schenke-LaylandPeter SeizerJulia MöllmannNikolaus MarxRobert FeilSusanne FeilRobert LukowskiOliver BorstTilman E SchäfferKarin Anne Lydia MüllerMeinrad P GawazDavid HeinzmannPublished in: Circulation research (2024)
Our study provides strong evidence of the pathogenic role of eCyPA in remodeling, myocardial stiffening, and dysfunction in heart failure. The findings suggest that antibody-based inhibition of eCyPA may offer a novel therapeutic strategy for nonischemic heart failure. Further research is needed to evaluate the translational potential of these interventions in human patients with cardiac hypertrophy.