Proinflammatory cytokines driving cardiotoxicity in Covid-19.

Maria Colzani Johannes Bargehr Frederica MesciaEleanor WilliamsVincent Knight-SchrijverJonathan LeeCharlotte SummersIrina I MohorianuKenneth G C SmithPaul A LyonsSanjay Sinha

Published in: Cardiovascular research (2023)

These results provide direct evidence that inflammatory cytokines are at least in part responsible for the cardiovascular damage seen in COVID-19 and characterise the downstream activated pathways in human cardiomyocytes. The serum signature of patients with severe disease indicates possible targets for therapeutic intervention.

Keyphrases

coronavirus disease
sars cov
endothelial cells
randomized controlled trial
respiratory syndrome coronavirus
early onset
pluripotent stem cells
high glucose