Peri-Prostatic Adipocyte-Released TGFβ Enhances Prostate Cancer Cell Motility by Upregulation of Connective Tissue Growth Factor.
Evelina La CivitaAntonietta LiottiMichele CennamoFelice CrocettoMatteo FerroPasquale LiguoroAmelia CimminoCiro ImbimboFrancesco BeguinotPietro FormisanoDaniela TerraccianoPublished in: Biomedicines (2021)
Collectively, our study showed that factors secreted by PPAT enhanced migration through CTGF upregulation in AI PCa cell lines. These findings reveal the potential of novel therapeutic strategies targeting adipocyte-released factors and TGFβ/CTGF axis to fight advanced PCa dissemination.
Keyphrases
- growth factor
- prostate cancer
- radical prostatectomy
- adipose tissue
- transforming growth factor
- insulin resistance
- single cell
- poor prognosis
- cell proliferation
- fatty acid
- signaling pathway
- artificial intelligence
- cell therapy
- genome wide
- type diabetes
- biofilm formation
- epithelial mesenchymal transition
- staphylococcus aureus
- cystic fibrosis
- machine learning
- pseudomonas aeruginosa
- long non coding rna
- gene expression
- risk assessment
- human health
- skeletal muscle
- drug delivery
- dna methylation