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Radiation synergizes with antitumor activity of CD13-targeted tissue factor in a HT1080 xenograft model of human soft tissue sarcoma.

Caroline BrandBurkhard GreveTobias BöllingHans T EichNormann WillichSaliha HarrachHeike HintelmannGeorg LenzRolf M MestersTorsten KesslerChristoph SchliemannWolfgang E BerdelChristian Schwöppe
Published in: PloS one (2020)
Irradiation renders tumor and tumor vascular cells procoagulant by PS upregulation on their outer surface and radiotherapy can significantly improve the therapeutic antitumor efficacy of tTF-NGR in the xenograft model used. This synergistic effect will influence design of future clinical combination studies.
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