Radiation synergizes with antitumor activity of CD13-targeted tissue factor in a HT1080 xenograft model of human soft tissue sarcoma.

Caroline BrandBurkhard GreveTobias BöllingHans T EichNormann WillichSaliha HarrachHeike HintelmannGeorg LenzRolf M MestersTorsten KesslerChristoph SchliemannWolfgang E BerdelChristian Schwöppe

Published in: PloS one (2020)

Irradiation renders tumor and tumor vascular cells procoagulant by PS upregulation on their outer surface and radiotherapy can significantly improve the therapeutic antitumor efficacy of tTF-NGR in the xenograft model used. This synergistic effect will influence design of future clinical combination studies.

Keyphrases

induced apoptosis
endothelial cells
radiation induced
early stage
signaling pathway
radiation therapy
cell proliferation
poor prognosis
cell cycle arrest
locally advanced
current status
endoplasmic reticulum stress
squamous cell carcinoma
cell death
pluripotent stem cells
case control
rectal cancer