Biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2 trial): study protocol for an international, prospective, randomised controlled multicentre trial.

Thilo von Groote Alexander ZarbockStefano RomagnoliMarlies OstermannJavier Ripollés-MelchorAntoine Guillaume Schneider Wim VandenbergheCéline MonardSilvia De RosaLucia CattinTim RahmelMichael AdamzikDiego PariseAngel Candela-TohaJan Gerrit HaakerUlrich GöbelAlice BernardNuttha LumlertgulPaula Fernández-Valdes-BangoIrene Romero BhathalA Suarez-de-la-RicaJan LarmannGianluca VillaSavino SpadaroHinnerk WulfChristian ArndtChristian PutensenRaquel García-ÁlvarezTimo BrandenburgerAntonio SiniscalchiRichard EllerkmannFlorian EspeterChristian PorschenMahan SadjadiKhaschayar Saadat-GilaniRaphael WeissJoachim GerssJohn KellumAlexander Zarbocknull null

Published in: BMJ open (2023)

NCT04647396.

Keyphrases

study protocol
randomized controlled trial
acute kidney injury
clinical trial
phase iii
phase ii
minimally invasive
open label
cardiac surgery
coronary artery bypass
double blind
cross sectional
surgical site infection
acute coronary syndrome
placebo controlled