A Pd-labile fluoroquinolone prodrug efficiently prevents biofilm formation on coated surfaces.
Josef BraunM Carmen Ortega-LiebanaAsier Unciti-BrocetaStephan A SieberPublished in: Organic & biomolecular chemistry (2024)
Surface-adhered bacteria on implants represent a major challenge for antibiotic treatment. We introduce hydrogel-coated surfaces loaded with tailored Pd-nanosheets which catalyze the release of antibiotics from inactive prodrugs. Masked and antibiotically inactive fluoroquinolone analogs were efficiently activated at the surface and prevented the formation of Staphylococcus aureus biofilms.
Keyphrases
- biofilm formation
- staphylococcus aureus
- candida albicans
- pseudomonas aeruginosa
- drug delivery
- escherichia coli
- cancer therapy
- wound healing
- methicillin resistant staphylococcus aureus
- drug release
- cystic fibrosis
- smoking cessation
- molecular docking
- quantum dots
- reduced graphene oxide
- highly efficient
- tissue engineering
- gold nanoparticles
- transition metal