Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models.

Aitor MartinezAlvaro Sanchez-MartinezJake T PickeringMadeleine J TwyningAna Terriente-FelixPo-Lin ChenChun-Hong ChenAlexander J Whitworth

Published in: Molecular neurodegeneration (2024)

Altogether, our studies indicate that Cisd accumulation during ageing and in Pink1/parkin mutants is a key driver of pathology by blocking mitophagy, and genetically and pharmacologically inhibiting CISD proteins may offer a potential target for therapeutic intervention.

Keyphrases

randomized controlled trial
oxidative stress
nlrp inflammasome
signaling pathway
mouse model
genome wide
gene expression
climate change