Alexander J Whitworth (Hélène Plun-Favreau, Helene Plun-Favreau)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 39

Top Venues

Molecular neurodegeneration

eLife

Life science alliance

Nature communications

University of Cambridge

University of Cambridge (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Cambridge Mar 01 2017

United Kingdom

Programme Leader :: MRC Mitochondrial Biology Unit

Medical Research Council Sep 01 2015 - Feb 28 2017

United Kingdom

Programme Leader :: Mitochondrial Biology Unit

University of Sheffield

United Kingdom

faculty :: Biomedical Science

University of Washington

United States

Post-doc :: Genome Sciences

Education History

University of Cambridge

United Kingdom

PHD :: Genetics

Imperial College London

United Kingdom

BSC :: Biochemistry

Publications

Aitor Martinez, Alvaro Sanchez-Martinez, Jake T Pickering, Madeleine J Twyning, Ana Terriente-Felix, Po-Lin Chen, Chun-Hong Chen, Alexander J Whitworth
Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models. Molecular neurodegeneration 19 (1) (2024)
Aitor Martinez, Alvaro Sanchez-Martinez, Jake T Pickering, Madeleine J Twyning, Ana Terriente-Felix, Po-Lin Chen, Chun-Hong Chen, Alexander J Whitworth
Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models. Molecular neurodegeneration 19 (1) (2024)
Aitor Martinez, Alvaro Sanchez-Martinez, Jake T Pickering, Madeleine J Twyning, Ana Terriente-Felix, Po-Lin Chen, Chun-Hong Chen, Alexander J Whitworth
Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models. Molecular neurodegeneration 19 (1) (2024)
Wing Hei Au, Leonor Miller-Fleming, Alvaro Sanchez-Martinez, James Ak Lee, Madeleine J Twyning, Hiran A Prag, Laura Raik, Scott P Allen, Pamela J Shaw, Laura Ferraiuolo, Heather Mortiboys, Alexander J Whitworth
Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes in C9orf72 ALS/FTD models. Life science alliance 7 (9) (2024)
Wing Hei Au, Leonor Miller-Fleming, Alvaro Sanchez-Martinez, James Ak Lee, Madeleine J Twyning, Hiran A Prag, Laura Raik, Scott P Allen, Pamela J Shaw, Laura Ferraiuolo, Heather Mortiboys, Alexander J Whitworth
Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes in C9orf72 ALS/FTD models. Life science alliance 7 (9) (2024)
Aitor Martinez, Alvaro Sanchez-Martinez, Jake T Pickering, Madeleine J Twyning, Ana Terriente-Felix, Po-Lin Chen, Chun-Hong Chen, Alexander J Whitworth
Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models. Molecular neurodegeneration 19 (1) (2024)
Aitor Martinez, Alvaro Sanchez-Martinez, Jake T Pickering, Madeleine J Twyning, Ana Terriente-Felix, Po-Lin Chen, Chun-Hong Chen, Alexander J Whitworth
Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models. Molecular neurodegeneration 19 (1) (2024)
Aitor Martinez, Alvaro Sanchez-Martinez, Jake T Pickering, Madeleine J Twyning, Ana Terriente-Felix, Po-Lin Chen, Chun-Hong Chen, Alexander J Whitworth
Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models. Molecular neurodegeneration 19 (1) (2024)
Wing Hei Au, Leonor Miller-Fleming, Alvaro Sanchez-Martinez, James Ak Lee, Madeleine J Twyning, Hiran A Prag, Laura Raik, Scott P Allen, Pamela J Shaw, Laura Ferraiuolo, Heather Mortiboys, Alexander J Whitworth
Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes in C9orf72 ALS/FTD models. Life science alliance 7 (9) (2024)
Aitor Martinez, Alvaro Sanchez-Martinez, Jake T Pickering, Madeleine J Twyning, Ana Terriente-Felix, Po-Lin Chen, Chun-Hong Chen, Alexander J Whitworth
Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models. Molecular neurodegeneration 19 (1) (2024)
Ahmed-Noor A Agip, Injae Chung, Alvaro Sanchez-Martinez, Alexander J Whitworth, Judy Hirst
Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster . eLife 12 (2023)
Lydia M Castelli, Ya-Hui Lin, Alvaro Sanchez-Martinez, Aytaç Gül, Kamallia Mohd Imran, Adrian Higginbottom, Santosh Kumar Upadhyay, Nóra M Márkus, Raquel R Martins, Johnathan Cooper-Knock, Claire Montmasson, Rebecca Cohen, Amy Walton, Claudia S Bauer, Kurt J De Vos, Richard J Mead, Mimoun Azzouz, Cyril Dominguez, Laura Ferraiuolo, Dame Pamela J Shaw, Alexander J Whitworth, Guillaume M Hautbergue
A cell-penetrant peptide blocking C9ORF72 -repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins. Science translational medicine 15 (685) (2023)
Lydia M Castelli, Ya-Hui Lin, Alvaro Sanchez-Martinez, Aytaç Gül, Kamallia Mohd Imran, Adrian Higginbottom, Santosh Kumar Upadhyay, Nóra M Márkus, Raquel R Martins, Johnathan Cooper-Knock, Claire Montmasson, Rebecca Cohen, Amy Walton, Claudia S Bauer, Kurt J De Vos, Richard J Mead, Mimoun Azzouz, Cyril Dominguez, Laura Ferraiuolo, Dame Pamela J Shaw, Alexander J Whitworth, Guillaume M Hautbergue
A cell-penetrant peptide blocking C9ORF72 -repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins. Science translational medicine 15 (685) (2023)
Sofia Mauri, Greta Bernardo, Aitor Martinez, Mariavittoria Favaro, Marta Trevisan, Gael Cobraiville, Christelle Vercheval, Federico Caicci, Alexander J Whitworth, Ziviani Elena
USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the Drosophila Brain and in Human Neurons. Cells 12 (8) (2023)
Amy R Hicks, Regina Hertfelder Reynolds, Ben O'Callaghan, Sonia Garcia Ruiz, Ana Luisa Gil Martinez, Juan Botia, Alexander J Whitworth, Mina Ryten
The non-specific lethal complex regulates genes and pathways genetically linked to Parkinson's disease. Brain : a journal of neurology (2023)
Ahmed-Noor A Agip, Injae Chung, Alvaro Sanchez-Martinez, Alexander J Whitworth, Judy Hirst
Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster . eLife 12 (2023)
Ahmed-Noor A Agip, Injae Chung, Alvaro Sanchez-Martinez, Alexander J Whitworth, Judy Hirst
Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster . eLife 12 (2023)
Ahmed-Noor A Agip, Injae Chung, Alvaro Sanchez-Martinez, Alexander J Whitworth, Judy Hirst
Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster . eLife 12 (2023)
Sylvia Varland, Rui Duarte Silva, Ine Kjosås, Alexandra Faustino, Annelies Bogaert, Maximillian Billmann, Hadi Boukhatmi, Barbara Kellen, Michael Costanzo, Adrian Drazic, Camilla Osberg, Katherine Chan, Xiang Zhang, Amy Hin Yan Tong, Simonetta Andreazza, Juliette J Lee, Lyudmila Nedyalkova, Matej Ušaj, Alexander J Whitworth, Brenda J Andrews, Jason Moffat, Chad L Myers, Kris Gevaert, Charles Boone, Rui Gonçalo Martinho, Thomas Arnesen
N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity. Nature communications 14 (1) (2023)
Sofia Mauri, Greta Bernardo, Aitor Martinez, Mariavittoria Favaro, Marta Trevisan, Gael Cobraiville, Christelle Vercheval, Federico Caicci, Alexander J Whitworth, Ziviani Elena
USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the Drosophila Brain and in Human Neurons. Cells 12 (8) (2023)
Alvaro Sanchez-Martinez, Aitor Martinez, Alexander J Whitworth
FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivo. PLoS biology 21 (8) (2023)
Sofia Mauri, Greta Bernardo, Aitor Martinez, Mariavittoria Favaro, Marta Trevisan, Gael Cobraiville, Christelle Vercheval, Federico Caicci, Alexander J Whitworth, Ziviani Elena
USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the Drosophila Brain and in Human Neurons. Cells 12 (8) (2023)
Ahmed-Noor A Agip, Injae Chung, Alvaro Sanchez-Martinez, Alexander J Whitworth, Judy Hirst
Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster . eLife 12 (2023)
Ahmed-Noor A Agip, Injae Chung, Alvaro Sanchez-Martinez, Alexander J Whitworth, Judy Hirst
Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster . eLife 12 (2023)
Lydia M Castelli, Ya-Hui Lin, Alvaro Sanchez-Martinez, Aytaç Gül, Kamallia Mohd Imran, Adrian Higginbottom, Santosh Kumar Upadhyay, Nóra M Márkus, Raquel R Martins, Johnathan Cooper-Knock, Claire Montmasson, Rebecca Cohen, Amy Walton, Claudia S Bauer, Kurt J De Vos, Richard J Mead, Mimoun Azzouz, Cyril Dominguez, Laura Ferraiuolo, Dame Pamela J Shaw, Alexander J Whitworth, Guillaume M Hautbergue
A cell-penetrant peptide blocking C9ORF72 -repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins. Science translational medicine 15 (685) (2023)
Marc P M Soutar, Daniela Melandri, Benjamin O'Callaghan, Emily Annuario, Amy E Monaghan, Natalie J Welsh, Karishma D'Sa, Sebastian Guelfi, David Zhang, Alan Pittman, Daniah Trabzuni, Anouk H A Verboven, Kylie S Pan, Demis A Kia, Magda Bictash, Sonia Gandhi, Henry Houlden, Mark R Cookson, Nael Nadif Kasri, Nicholas W Wood, Andrew B Singleton, John Hardy, Paul J Whiting, Cornelis Blauwendraat, Alexander J Whitworth, Claudia Manzoni, Mina Ryten, Patrick A Lewis, Alexander J Whitworth
Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci. Brain : a journal of neurology (2022)
Maeve Long, Alvaro Sanchez-Martinez, Marianna Longo, Fumi Suomi, Hans Stenlund, Annika I Johansson, Homa Ehsan, Veijo T Salo, Lambert Montava-Garriga, Seyedehshima Naddafi, Elina Ikonen, Ian G Ganley, Alexander J Whitworth, Thomas G McWilliams
DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron depletion. The EMBO journal 41 (10) (2022)
Joanne L Usher, Alvaro Sanchez-Martinez, Ana Terriente-Felix, Po-Lin Chen, Juliette J Lee, Chun-Hong Chen, Alexander J Whitworth
Parkin drives pS65-Ub turnover independently of canonical autophagy in Drosophila. EMBO reports 23 (12) (2022)
Victoria L Hewitt, Leonor Miller-Fleming, Madeleine J Twyning, Simonetta Andreazza, Francesca Mattedi, Julien Prudent, Franck Polleux, Alessio Vagnoni, Alexander J Whitworth
Decreasing pdzd8-mediated mito-ER contacts improves organismal fitness and mitigates Aβ 42 toxicity. Life science alliance 5 (11) (2022)
Pedro Rebelo-Guiomar, Simone Pellegrino, Kyle C Dent, Aldema Sas-Chen, Leonor Miller-Fleming, Caterina Garone, Lindsey Van Haute, Jack F Rogan, Adam Dinan, Andrew E Firth, Byron Andrews, Alexander J Whitworth, Schraga Schwartz, Alan John Warren, Michal Minczuk
A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit. Nature communications 13 (1) (2022)
Juliette J Lee, Simonetta Andreazza, Alexander J Whitworth
The STING pathway does not contribute to behavioural or mitochondrial phenotypes in Drosophila Pink1/parkin or mtDNA mutator models. Scientific reports 10 (1) (2020)
Ana Terriente-Felix, Emma Louise Wilson, Alexander J Whitworth
Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes. PLoS genetics 16 (10) (2020)
Federica De Lazzari, Federica Sandrelli, Alexander J Whitworth, Marco Bisaglia
Antioxidant Therapy in Parkinson's Disease: Insights from Drosophila melanogaster. Antioxidants (Basel, Switzerland) 9 (1) (2020)
Sophia von Stockum, Alvaro Sanchez-Martinez, Samantha Corrà, Joy Chakraborty, Elena Marchesan, Locatello Lisa, Caterina Da Rè, Paola Cusumano, Federico Caicci, Vanni Ferrari, Rodolfo Costa, Luigi Bubacco, Maria Berica Rasotto, Ildiko Szabo, Alexander J Whitworth, Luca Scorrano, Ziviani Elena
Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction. Life science alliance 2 (2) (2019)
Simonetta Andreazza, Colby L Samstag, Alvaro Sanchez-Martinez, Erika Fernández-Vizarra, Aurora Gomez-Duran, Juliette J Lee, Roberta Tufi, Michael J Hipp, Elizabeth K Schmidt, Thomas J Nicholls, Payam A Gammage, Patrick F Chinnery, Michal Minczuk, Leo J Pallanck, Scott R Kennedy, Alexander J Whitworth
Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila. Nature communications 10 (1) (2019)
Juliette J Lee, Alvaro Sanchez-Martinez, Aitor Martinez Zarate, Cristiane Benincá, Ugo Mayor, Michael J Clague, Alexander J Whitworth
Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin. The Journal of cell biology 217 (5) (2018)
Domenica Lovero, Luca Giordano, René Massimiliano Marsano, Alvaro Sanchez-Martinez, Hadi Boukhatmi, Maik Drechsler, Marta Oliva, Alexander J Whitworth, Damiano Porcelli, Corrado Caggese
Characterization of Drosophila ATPsynC mutants as a new model of mitochondrial ATP synthase disorders. PloS one 13 (8) (2018)
Guillaume M Hautbergue, Lydia M Castelli, Laura Ferraiuolo, Alvaro Sanchez-Martinez, Johnathan Cooper-Knock, Adrian Higginbottom, Ya-Hui Lin, Claudia S Bauer, Jennifer E Dodd, Monika A Myszczynska, Sarah M Alam, Pierre Garneret, Jayanth S Chandran, Evangelia Karyka, Matthew J Stopford, Emma F Smith, Janine Kirby, Kathrin C Meyer, Brian K Kaspar, Adrian M Isaacs, Sherif F El-Khamisy, Kurt J De Vos, Ke Ning, Mimoun Azzouz, Alexander J Whitworth, Pamela J Shaw
SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits. Nature communications 8 (2017)
Christopher P Webster, Emma F Smith, Claudia S Bauer, Annekathrin Moller, Guillaume M Hautbergue, Laura Ferraiuolo, Monika A Myszczynska, Adrian Higginbottom, Matthew J Walsh, Alexander J Whitworth, Brian K Kaspar, Kathrin Meyer, Pamela J Shaw, Andrew J Grierson, Kurt J De Vos
The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy. The EMBO journal 35 (15) (2016)

Alexander J Whitworth.css-eqlu8i{font-size:small;padding-left:4px;} (Hélène Plun-Favreau, Helene Plun-Favreau)

Publication Activity (10 Years)

Top Topics

Top Venues

Alexander J Whitworth (Hélène Plun-Favreau, Helene Plun-Favreau)