An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection.
Carly G K ZieglerAnna H OwingsMichelle Galeas-PenaSamuel W KazerVincent N MiaoAndrew W NaviaYing TangJoshua D BromleyPeter LotfyMeredith SloanHannah LairdHaley B WilliamsMicayla GeorgeRiley S DrakeYilianys PrideGeorge E AbrahamMichal SenitkoTanya O RobinsonGill DiamondMichail S LionakisAlex K ShalekJosé Ordovas-MontañesBruce H HorwitzSarah Camille GloverPublished in: Microbiology spectrum (2024)
In this paper, we present an analysis suggesting that symptomatic and asymptomatic fungal coinfections can impact patient disease progression during COVID-19 hospitalization. By looking into the presence of other pathogens and their effect on the host immune response during COVID-19 hospitalizations, we aim to offer insight into an underestimated scenario, furthering our current knowledge of determinants of severity that could be considered for future diagnostic and intervention strategies.