MiR-125b-5p modulates the function of regulatory T cells in tumor microenvironment by targeting TNFR2.
Mengmeng JiangYang YangLiling NiuPing LiYibo ChenPing LiaoYifei WangJingbin ZhengFengyang ChenHuanhuan HeHui LiXin ChenPublished in: Journal for immunotherapy of cancer (2022)
Our study for the first time found that the expression of TNFR2 by Tregs was regulated by miR-125b-5p. Our results showed that miR-125b-5p had the capacity to inhibit the expression of TNFR2 and immunosuppressive activity of Tregs and consequently enhanced the antitumor efficacy. This property of miR-125b-5p may be therapeutically harnessed in the treatment of human cancers.