Oleic acid influences the adipogenesis of 3T3-L1 cells via DNA Methylation and may predispose to obesity and obesity-related disorders.
Malgorzata Malodobra-MazurAneta CierzniakTadeusz DoboszPublished in: Lipids in health and disease (2019)
Oleic acid affected the methylation of Pparγ and C/ebpα promoters, what correlated with higher expression. Furthermore, examined free fatty acids influenced the phenotype of mature adipocytes, especially insulin signaling pathway and adipokine secretion.
Keyphrases
- high fat diet induced
- insulin resistance
- dna methylation
- type diabetes
- induced apoptosis
- signaling pathway
- fatty acid
- metabolic syndrome
- weight loss
- adipose tissue
- genome wide
- weight gain
- poor prognosis
- cell cycle arrest
- gene expression
- pi k akt
- glycemic control
- skeletal muscle
- endoplasmic reticulum stress
- epithelial mesenchymal transition
- binding protein
- copy number