NEDD4 regulates ubiquitination and stability of the cell adhesion molecule IGPR-1 via lysosomal pathway.

Linzi SunRazie AmraeiNader Rahimi

Published in: Journal of biomedical science (2021)

NEDD4 ubiquitin E3 ligase binds to and mediates polyubiquitination of IGPR-1 leading to its lysosomal-dependent degradation. NEDD4 is a key regulator of IGPR-1 expression with implication in the therapeutic targeting of IGPR-1 in human cancers.

Keyphrases

cell adhesion
endothelial cells
poor prognosis
transcription factor
small molecule
induced pluripotent stem cells
cancer therapy
pluripotent stem cells
binding protein
young adults
drug delivery