Precision Medicine: Steps along the Road to Combat Human Cancer.
Samuel F NassarKhadir RaddassiBaljit UbhiJoseph DoktorskiAhmad Abdulaziz AbulabanPublished in: Cells (2020)
The diagnosis and treatment of diseases such as cancer is becoming more accurate and specialized with the advent of precision medicine techniques, research and treatments. Reaching down to the cellular and even sub-cellular level, diagnostic tests can pinpoint specific, individual information from each patient, and guide providers to a more accurate plan of treatment. With this advanced knowledge, researchers and providers can better gauge the effectiveness of drugs, radiation, and other therapies, which is bound to lead to a more accurate, if not more positive, prognosis. As precision medicine becomes more established, new techniques, equipment, materials and testing methods will be required. Herein, we will examine the recent innovations in assays, devices and software, along with next generation sequencing in genomics diagnostics which are in use or are being developed for personalized medicine. So as to avoid duplication and produce the fullest possible benefit, all involved must be strongly encouraged to collaborate, across national borders, public and private sectors, science, medicine and academia alike. In this paper we will offer recommendations for tools, research and development, along with ideas for implementation. We plan to begin with discussion of the lessons learned to date, and the current research on pharmacogenomics. Given the steady stream of advances in imaging mass spectrometry and nanoLC-MS/MS, and use of genomic, proteomic and metabolomics biomarkers to distinguish healthy tissue from diseased cells, there is great potential to utilize pharmacogenomics to tailor a drug or drugs to a particular cohort of patients. Such efforts very well may bring increased hope for small groups of non-responders and those who have demonstrated adverse reactions to current treatments.
Keyphrases
- high resolution
- mass spectrometry
- healthcare
- papillary thyroid
- adverse drug
- end stage renal disease
- ms ms
- quality improvement
- chronic kidney disease
- liquid chromatography
- squamous cell
- endothelial cells
- newly diagnosed
- induced apoptosis
- primary care
- ejection fraction
- randomized controlled trial
- public health
- copy number
- systematic review
- high performance liquid chromatography
- palliative care
- childhood cancer
- high throughput
- prognostic factors
- squamous cell carcinoma
- mental health
- liquid chromatography tandem mass spectrometry
- radiation therapy
- case report
- health insurance
- photodynamic therapy
- ultrasound guided
- single cell
- cell death
- cell proliferation
- gene expression
- pluripotent stem cells
- risk assessment
- electronic health record
- simultaneous determination
- health information
- fluorescence imaging
- smoking cessation