Effect of Quercetin on the fructose-activated human hepatic stellate cells, LX-2, an in-vitro study.

Elham ShakerianReza AfarinRasoul AkbariNarges Mohammadtaghvaei

Published in: Molecular biology reports (2022)

Quercetin is effective in reducing the expression of fibrogenic genes in fructose-activated human HSCs through downregulation of the TGF-β/smad3 signaling pathway. Therefore, Quercetin possesses significant antifibrotic properties in hepatic fibrosis.

Keyphrases

signaling pathway
endothelial cells
induced apoptosis
transforming growth factor
induced pluripotent stem cells
poor prognosis
pluripotent stem cells
cell proliferation
gene expression
endoplasmic reticulum stress
long non coding rna