Relationship between insulin sensitivity and gene expression in human skeletal muscle.
Hemang M ParikhTarg ElgzyriAmra AlibegovicNatalie HiscockOla EkströmKarl-Fredrik ErikssonAllan VaagLeif C GroopKristoffer StrömOla HanssonPublished in: BMC endocrine disorders (2021)
The muscle expression of 180 genes were correlated with insulin sensitivity. These data suggest that activation of genes involved in lipid metabolism, e.g. SIRT2, and genes regulating autophagy and mTOR signaling, e.g. FBXW5, are associated with increased insulin sensitivity in human skeletal muscle, reflecting a highly flexible nutrient sensing.
Keyphrases
- skeletal muscle
- gene expression
- endothelial cells
- insulin resistance
- genome wide
- induced pluripotent stem cells
- pluripotent stem cells
- poor prognosis
- dna methylation
- cell death
- cell proliferation
- signaling pathway
- endoplasmic reticulum stress
- big data
- machine learning
- ischemia reperfusion injury
- bioinformatics analysis