Analysis of HLA-G protein expression in leprosy.

Camila Rodrigues da SilvaLucas Henrique Ferreira SampaioMaurício Barcelos CostaMaria Auxiliadora de Paula Carneiro CysneirosIbrahim Abiodoun SadissouMirian Lane de Oliveira Rodrigues CastilhoJonathan Ballico de MoraesEduardo Antonio DonadiIsabela Jubé Wastowski

Published in: Immunogenetics (2020)

The aim of this study was to evaluate the expression of human leukocyte antigen G (HLA-G) in leprosy. Biopsy and serum samples were collected from 18 patients presenting with leprosy and from healthy controls. Samples were analyzed using immunohistochemistry and ELISA techniques. HLA-G expression was observed in biopsy samples of all patients. The healthy control samples were consistently negative for HLA-G expression. Control plasma samples displayed significantly higher HLA-G expression than those from the patients (p < 0.01). These results are the first demonstration of the expression of HLA-G in leprosy.

Keyphrases

poor prognosis
end stage renal disease
ejection fraction
newly diagnosed
binding protein
prognostic factors
patient reported
pluripotent stem cells