Randomized Phase II Trial of Proton Craniospinal Irradiation Versus Photon Involved-Field Radiotherapy for Patients With Solid Tumor Leptomeningeal Metastasis.

Jonathan T Yang N Ari WijetungaElena PentsovaSuzanne L Wolden Robert J Young Denise D CorreaZhigang ZhangJunting ZhengAlexa StecklerWeronika BucwinskaAshley BernsteinAllison Betof Warner Helena Alexandra YuMark G KrisAndrew D SeidmanJessica A Wilcox Rachna Malani Andrew L LinLisa M DeAngelisNancy Y LeeSimon N PowellAdrienne A Boire

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2022)

Compared with photon IFRT, we found pCSI improved CNS PFS and OS for patients with non-small-cell lung cancer and breast cancer with LM with no increase in serious TAEs.

Keyphrases

open label
placebo controlled
living cells
double blind
radiation induced
early stage
phase iii
phase ii
monte carlo
locally advanced
radiation therapy
blood brain barrier
cerebrospinal fluid
clinical trial
fluorescent probe
randomized controlled trial
rectal cancer