Helena Alexandra Yu (Helena Yu, Helena A Yu)

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 28

Top Topics

Tyrosine Kinase

Small Cell Lung Cancer

Epidermal Growth Factor Receptor

Top Venues

Clinical cancer research : an official journal of the American Association for Cancer Research

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

JCO precision oncology

Cancer discovery

This page only lists publications with an associated author ORCID identifier.

Publications

Mark Y Jeng, Helena Alexandra Yu
Leptomeningeal Metastasis in the Era of CNS-Penetrant Tyrosine Kinase Inhibitor Therapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)
Mark Y Jeng, Helena Alexandra Yu
Leptomeningeal Metastasis in the Era of CNS-Penetrant Tyrosine Kinase Inhibitor Therapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 42 (23) (2024)
Monica F Chen, Soo-Ryum Yang, Jessica J Tao, Antoine Desilets, Eli L Diamond, Clare J Wilhem, Ezra Y Rosen, Yixiao Gong, Kerry Mullaney, Jean Torrisi, Robert J Young, Romel Somwar, Helena Alexandra Yu, Mark G Kris, Gregory J Riely, Maria E Arcila, Marc Ladanyi, Mark T A Donoghue, Neal X Rosen, Rona Yaeger, Alexander E Drilon, Yonina R Murciano-Goroff, Michael D Offin
Tumor-agnostic genomic and clinical analysis of BRAF fusions identify actionable targets. Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Monica F Chen, Soo-Ryum Yang, Jessica J Tao, Antoine Desilets, Eli L Diamond, Clare J Wilhem, Ezra Y Rosen, Yixiao Gong, Kerry Mullaney, Jean Torrisi, Robert J Young, Romel Somwar, Helena Alexandra Yu, Mark G Kris, Gregory J Riely, Maria E Arcila, Marc Ladanyi, Mark T A Donoghue, Neal X Rosen, Rona Yaeger, Alexander E Drilon, Yonina R Murciano-Goroff, Michael D Offin
Tumor-agnostic genomic and clinical analysis of BRAF fusions identify actionable targets. Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Natasha Rekhtman, Sam E Tischfield, Christopher Antonio Febres-Aldana, Jake June-Koo Lee, Jason C Chang, Benjamin O Herzberg, Pier Selenica, Hyung Jun Woo, Chad M Vanderbilt, Soo-Ryum Yang, Fei Xu, Anita S Bowman, Edaise M Da Silva, Anne Marie Noronha, Diana L Mandelker, Miika Mehine, Semanti Mukherjee, Juan Blanco-Heredia, John J Orgera, Gouri J Nanjangud, Marina K Baine, Rania Gaber Aly, Jennifer L Sauter, William D Travis, Omid Savari, Andre L Moreira, Christina J Falcon, Francis M Bodd, Christina E Wilson, Jacklynn V Sienty, Parvathy Manoj, Harsha Sridhar, Lu Wang, Noura J Choudhury, Michael D Offin, Helena Alexandra Yu, Álvaro Quintanal-Villalonga, Michael F Berger, Marc Ladanyi, Mark T A Donoghue, Jorge Sergio Reis-Filho, Charles M Rudin
Chromothripsis-mediated small cell lung carcinoma. Cancer discovery (2024)
Monica F Chen, Zihe Song, Helena Alexandra Yu, Lecia V Sequist, Christine M Lovly, Edith P Mitchell, Jeffrey A Moscow, Robert C Gray, Victoria Wang, Lisa Meier McShane, Lawrence V Rubinstein, David R Patton, P Mickey Williams, Stanley R Hamilton, Yoshie Umemura, James V Tricoli, Barbara A Conley, Carlos L Arteaga, Lyndsay N Harris, Peter J O'Dwyer, Alice P Chen, Keith T Flaherty
Phase II Study of Osimertinib in Patients With Epidermal Growth Factor Receptor Mutations: Results From the NCI-MATCH ECOG-ACRIN (EAY131) Trial Subprotocol E. JCO precision oncology 8 (2024)
Monica F Chen, Soo-Ryum Yang, Jessica J Tao, Antoine Desilets, Eli L Diamond, Clare J Wilhem, Ezra Y Rosen, Yixiao Gong, Kerry Mullaney, Jean Torrisi, Robert J Young, Romel Somwar, Helena Alexandra Yu, Mark G Kris, Gregory J Riely, Maria E Arcila, Marc Ladanyi, Mark T A Donoghue, Neal X Rosen, Rona Yaeger, Alexander E Drilon, Yonina R Murciano-Goroff, Michael D Offin
Tumor-agnostic genomic and clinical analysis of BRAF fusions identify actionable targets. Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Monica F Chen, Soo-Ryum Yang, Jessica J Tao, Antoine Desilets, Eli L Diamond, Clare J Wilhem, Ezra Y Rosen, Yixiao Gong, Kerry Mullaney, Jean Torrisi, Robert J Young, Romel Somwar, Helena Alexandra Yu, Mark G Kris, Gregory J Riely, Maria E Arcila, Marc Ladanyi, Mark T A Donoghue, Neal X Rosen, Rona Yaeger, Alexander E Drilon, Yonina R Murciano-Goroff, Michael D Offin
Tumor-Agnostic Genomic and Clinical Analysis of BRAF Fusions Identifies Actionable Targets. Clinical cancer research : an official journal of the American Association for Cancer Research 30 (17) (2024)
Monica F Chen, Zihe Song, Helena Alexandra Yu, Lecia V Sequist, Christine M Lovly, Edith P Mitchell, Jeffrey A Moscow, Robert C Gray, Victoria Wang, Lisa Meier McShane, Lawrence V Rubinstein, David R Patton, P Mickey Williams, Stanley R Hamilton, Yoshie Umemura, James V Tricoli, Barbara A Conley, Carlos L Arteaga, Lyndsay N Harris, Peter J O'Dwyer, Alice P Chen, Keith T Flaherty
Phase II Study of Osimertinib in Patients With Epidermal Growth Factor Receptor Mutations: Results From the NCI-MATCH ECOG-ACRIN (EAY131) Trial Subprotocol E. JCO precision oncology 8 (2024)
Monica F Chen, Zihe Song, Helena Alexandra Yu, Lecia V Sequist, Christine M Lovly, Edith P Mitchell, Jeffrey A Moscow, Robert C Gray, Victoria Wang, Lisa Meier McShane, Lawrence V Rubinstein, David R Patton, P Mickey Williams, Stanley R Hamilton, Yoshie Umemura, James V Tricoli, Barbara A Conley, Carlos L Arteaga, Lyndsay N Harris, Peter J O'Dwyer, Alice P Chen, Keith T Flaherty
Phase II Study of Osimertinib in Patients With Epidermal Growth Factor Receptor Mutations: Results From the NCI-MATCH ECOG-ACRIN (EAY131) Trial Subprotocol E. JCO precision oncology 8 (2024)
Monica F Chen, Soo-Ryum Yang, Jessica J Tao, Antoine Desilets, Eli L Diamond, Clare J Wilhem, Ezra Y Rosen, Yixiao Gong, Kerry Mullaney, Jean Torrisi, Robert J Young, Romel Somwar, Helena Alexandra Yu, Mark G Kris, Gregory J Riely, Maria E Arcila, Marc Ladanyi, Mark T A Donoghue, Neal X Rosen, Rona Yaeger, Alexander E Drilon, Yonina R Murciano-Goroff, Michael D Offin
Tumor-agnostic genomic and clinical analysis of BRAF fusions identify actionable targets. Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Mark Y Jeng, Helena Alexandra Yu
Leptomeningeal Metastasis in the Era of CNS-Penetrant Tyrosine Kinase Inhibitor Therapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 42 (23) (2024)
Arielle Elkrief, Meagan Montesion, Smruthy S Sivakumar, Caryn R Hale, Anita S Bowman, Ayyuce Begum Bektas, Martina Bradic, Wenfei Kang, Eric Chan, Pooja Gogia, Katia Manova-Todorova, Douglas A Mata, Jacklynn V Egger, Hira Rizvi, Nicolas D Socci, Daniel W Kelly, Eric Rosiek, Fanli Meng, Grittney Tam, Ning Fan, Alexander E Drilon, Helena Alexandra Yu, Gregory J Riely, Natasha Rekhtman, Álvaro Quintanal-Villalonga, Snjezana Dogan, Umeshkumar K Bhanot, Mithat Gönen, Brian R Loomis, Matthew D Hellmann, Adam J Schoenfeld, Marc Ladanyi, Charles M Rudin, Chad M Vanderbilt
Intratumoral Escherichia Is Associated With Improved Survival to Single-Agent Immune Checkpoint Inhibition in Patients With Advanced Non-Small-Cell Lung Cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)
Julia Rotow, Jyoti D Patel, Matthew P Hanley, Helena Alexandra Yu, Mark M Awad, Jonathan Wade Goldman, Hovav Nechushtan, Matthias Scheffler, Allen Chung-Cheng Huang, Senthil Rajappa, Guilherme Harada, Sarah Clifford, Alison D Santucci, Laura Silva, Rebecca Tupper, Geoffrey R Oxnard, Jennifer Kherani, Alexander E Drilon
Osimertinib and selpercatinib efficacy, safety, and resistance in a multicenter, prospectively treated cohort of EGFR-mutant and RET fusion-positive lung cancers. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Alissa J Cooper, Helena Alexandra Yu
The Promise and Limitations of Neoadjuvant Immune-Checkpoint Blockade in Resectable Non-Small Cell Lung Cancer. Cancer discovery 13 (11) (2023)
Helena Alexandra Yu, Yasushi Goto, Hidetoshi Hayashi, Enriqueta Felip Font, James Chih-Hsin Yang, Martin Reck, Kiyotaka Yoh, Se-Hoon Lee, Luis G Paz-Ares, Benjamin Besse, Paolo Bironzo, Dong Wan Kim, Melissa Lynne Johnson, Yi-Long Wu, Thomas John, Steven Kao, Toshiyuki Kozuki, Erminia Massarelli, Jyoti D Patel, Egbert F Smit, Karen L Reckamp, Qian Dong, Pomy Shrestha, Pang-Dian Fan, Parul Patel, Andrea Sporchia, David W Sternberg, Dalila Sellami, Pasi A Janne
HERTHENA-Lung01, a Phase II Trial of Patritumab Deruxtecan (HER3-DXd) in Epidermal Growth Factor Receptor-Mutated Non-Small-Cell Lung Cancer After Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy and Platinum-Based Chemotherapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
Zofia Piotrowska, Daniel Shao-Weng Tan, Egbert F Smit, Alexander I Spira, Ross Andrew Soo, Danny Nguyen, Victor Ho Fun Lee, James Chih-Hsin Yang, Vamsidhar Velcheti, John M Wrangle, Mark A Socinski, Marianna Koczywas, John E Janik, Jeffrey Jones, Helena Alexandra Yu
Safety, Tolerability, and Antitumor Activity of Zipalertinib Among Patients With Non-Small-Cell Lung Cancer Harboring Epidermal Growth Factor Receptor Exon 20 Insertions. Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
Tony S K Mok, Pasi A Janne, Makoto Nishio, Silvia Novello, Martin Reck, Conor E Steuer, Yi-Long Wu, Ronan Fougeray, Pang-Dian Fan, Jie Meng, David W Sternberg, Stephen Esker, Helena Alexandra Yu
HERTHENA-Lung02: phase III study of patritumab deruxtecan in advanced EGFR -mutated NSCLC after a third-generation EGFR TKI. Future oncology (London, England) (2023)
Arielle Elkrief, Alex Makhnin, Khadeja A Moses, Linda S Ahn, Isabel R Preeshagul, Afsheen N Iqbal, Sara A Hayes, Andrew J Plodkowski, Paul K Paik, Marc Ladanyi, Mark G Kris, Gregory J Riely, Franziska Michor, Helena Alexandra Yu
Brief report: Combination of Osimertinib and Dacomitinib to mitigate primary and acquired resistance in EGFR-mutant lung adenocarcinomas. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Michael J Grant, Jacqueline V Aredo, Jacqueline H Starrett, Paul Stockhammer, Iris K van Alderwerelt van Rosenburgh, Anna Wurtz, Andrew J Piper-Vallillo, Zofia Piotrowska, Christina J Falcon, Helena Alexandra Yu, Charu Aggarwal, Dylan G Scholes, Tejas Patil, Christina Nguyen, Manali Phadke, Fang-Yong Li, Joel W Neal, Mark A Lemmon, Zenta Walther, Katerina Politi, Sarah B Goldberg
Efficacy of osimertinib in patients with lung cancer positive for uncommon EGFR exon 19 deletion mutations. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Deborah R Caswell, Philippe Gui, Manasi K Mayekar, Emily K Law, Oriol Pich, Chris Bailey, Jesse Boumelha, D Lucas Kerr, Collin M Blakely, Tadashi Manabe, Carlos Martinez-Ruiz, Bjorn Bakker, Juan De Dios Palomino Villcas, Natalie I Vokes, Michelle Dietzen, Mihaela Angelova, Beatrice Gini, Whitney Tamaki, Paul Allegakoen, Wei Wu, Timothy J Humpton, William Hill, Mona Tomaschko, Wei-Ting Lu, Franziska Haderk, Maise Al Bakir, Ai Nagano, Francisco Gimeno-Valiente, Sophie de Carné Trécesson, Roberto Vendramin, Vittorio Barbè, Miriam Mugabo, Clare E Weeden, Andrew Rowan, Caroline E McCoach, Bruna Almeida, Mary Green, Carlos Gomez, Shigeki Nanjo, Dora Barbosa, Chris Moore, Joanna Przewrocka, James R M Black, Eva Grönroos, Alejandro Suarez-Bonnet, Simon Lawrence Priestnall, Caroline Zverev, Scott Lighterness, James Cormack, Victor Olivas, Lauren Cech, Trisha Andrews, Brandon Rule, Yuwei Jiao, Xinzhu Zhang, Paul Ashford, Cameron Durfee, Subramanian Venkatesan, Nuri Alpay Temiz, Lisa Tan, Lindsay K Larson, Prokopios P Argyris, William L Brown, Elizabeth A Yu, Julia K Rotow, Udayan Guha, Nitin Roper, Johnny Yu, Rachel Isaksson Vogel, Nicholas J Thomas, Antonio Marra, Pier Selenica, Helena Alexandra Yu, Samuel F Bakhoum, Su Kit Chew, Jorge Sergio Reis-Filho, Mariam Jamal-Hanjani, Karen H Vousden, Nicholas McGranahan, Eliezer Van Allen, Nnennaya Kanu, Reuben Stewart Harris, Julian Downward, Trever G Bivona, Charles Swanton
The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance. Nature genetics (2023)
Anna Skakodub, Henry S Walch, Kathryn R Tringale, Jordan Eichholz, Brandon S Imber, Harish N Vasudevan, Bob T Li, Nelson S Moss, Kenny Kwok Hei Yu, Boris A Mueller, Simon N Powell, Pedram Razavi, Helena Alexandra Yu, Jorge Sergio Reis-Filho, Daniel Gomez, Nikolaus Schultz, Luke R G Pike
Genomic analysis and clinical correlations of non-small cell lung cancer brain metastasis. Nature communications 14 (1) (2023)
Arielle Elkrief, Alex Makhnin, Khadeja A Moses, Linda S Ahn, Isabel R Preeshagul, Afsheen N Iqbal, Sara A Hayes, Andrew J Plodkowski, Paul K Paik, Marc Ladanyi, Mark G Kris, Gregory J Riely, Franziska Michor, Helena Alexandra Yu
Brief report: Combination of Osimertinib and Dacomitinib to mitigate primary and acquired resistance in EGFR-mutant lung adenocarcinomas. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Justin Jee, Emily S Lebow, Randy Yeh, Jeeban P Das, Azadeh Namakydoust, Paul K Paik, Jamie E Chaft, Gowtham Jayakumaran, Angela Rose Brannon, Ryma Benayed, Ahmet Zehir, Mark Donoghue, Nikolaus Schultz, Debyani Chakravarty, Ritika Kundra, Ramyasree Madupuri, Yonina R Murciano-Goroff, Hai-Yan Tu, Chong-Rui Xu, Andrés Martinez, Clare Wilhelm, Jesse Galle, Bobby Daly, Helena Alexandra Yu, Michael D Offin, Matthew D Hellmann, Piro Lito, Kathryn C Arbour, Marjorie G Zauderer, Mark G Kris, Kenneth K Ng, Juliana Eng, Isabel Preeshagul, W Victoria Lai, John J Fiore, Afsheen Iqbal, Daniela Molena, Gaetano Rocco, Bernard J Park, Lee P Lim, Mark Li, Candace Tong-Li, Madhawa De Silva, David L Chan, Connie I Diakos, Malinda Itchins, Stephen John Clarke, Nick Pavlakis, Adrian Lee, Natasha Rekhtman, Jason Chang, William D Travis, Gregory J Riely, David B Solit, Mithat Gonen, Valerie W Rusch, Andreas Rimner, Daniel Gomez, Alexander E Drilon, Howard I Scher, Sohrab P Shah, Michael F Berger, Maria E Arcila, Marc Ladanyi, Ross L Levine, Ronglai Shen, Pedram Razavi, Jorge Sergio Reis-Filho, David R Jones, Charles M Rudin, James M Isbell, Bob T Li
Overall survival with circulating tumor DNA-guided therapy in advanced non-small-cell lung cancer. Nature medicine 28 (11) (2022)
Ryan J Hartmaier, Aleksandra A Markovets, Myung-Ju Ahn, Lecia V Sequist, Ji-Youn Han, Byoung Chul Cho, Helena Alexandra Yu, Sang-We Kim, James Chih-Hsin Yang, Jong Seok Lee, Wu-Chou Su, Dariusz Mirosław Kowalski, Sergey V Orlov, Song Ren, Paul Frewer, Xiaoling Ou, Darren Ae Cross, Nisha Kurian, Mireille Cantarini, Pasi A Janne
Osimertinib+Savolitinib to Overcome Acquired MET-Mediated Resistance in Epidermal Growth Factor Receptor Mutated MET-Amplified Non-Small Cell Lung Cancer: TATTON. Cancer discovery (2022)
Jonathan T Yang, N Ari Wijetunga, Elena Pentsova, Suzanne L Wolden, Robert J Young, Denise D Correa, Zhigang Zhang, Junting Zheng, Alexa Steckler, Weronika Bucwinska, Ashley Bernstein, Allison Betof Warner, Helena Alexandra Yu, Mark G Kris, Andrew D Seidman, Jessica A Wilcox, Rachna Malani, Andrew L Lin, Lisa M DeAngelis, Nancy Y Lee, Simon N Powell, Adrienne A Boire
Randomized Phase II Trial of Proton Craniospinal Irradiation Versus Photon Involved-Field Radiotherapy for Patients With Solid Tumor Leptomeningeal Metastasis. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 40 (33) (2022)
Hiroki Sato, Daisuke Kubota, Huan Qiao, Achim Jungbluth, Natasha Rekhtman, Adam J Schoenfeld, Helena Alexandra Yu, Gregory J Riely, Shinichi Toyooka, Christine M Lovly, Paul K Paik, Marc Ladanyi, Pang-Dian Fan
SRC Family Kinase Inhibition Targets YES1 and YAP1 as Primary Drivers of Lung Cancer and as Mediators of Acquired Resistance to ALK and Epidermal Growth Factor Receptor Inhibitors. JCO precision oncology 6 (2022)
Álvaro Quintanal-Villalonga, Joseph M Chan, Helena Alexandra Yu, Dana Pe'er, Charles L Sawyers, Triparna Sen, Charles M Rudin
Lineage plasticity in cancer: a shared pathway of therapeutic resistance. Nature reviews. Clinical oncology 17 (6) (2020)