Listening to the elephant in the room: response-shift effects in clinical trials research.
Carolyn Emily SchwartzI-Chan HuangGudrun Elin RohdeRichard L SkolaskyPublished in: Journal of patient-reported outcomes (2022)
This scoping review supported the presumption that response shift phenomena obfuscate treatment benefits and revealed a greater intervention effect after integrating response-shift related changes. The formal consideration of response-shift effects in clinical trials research will not only improve estimation of treatment effects but will also integrate the inherent healing process of treatments.