1α, 25-Dihydroxyvitamin D3 alters ectonucleotidase expression and activity in human cutaneous melanoma cells.
Margarete Dulce BagatiniKalyne BertolinAlessandra BridiLuana Paula PelinsonBeatriz da Silva Rosa BonadimanMichele Mainardi PillatPaulo Bayard Dias GonçalvesHenning UlrichMaria Rosa Chitolina SchetingerVera Maria MorschPublished in: Journal of cellular biochemistry (2018)
To the best of our knowledge, we showed for the first time a mechanism of control of adenosine production via modulation of the purinergic system in cutaneous melanoma cells treated with the active metabolite of vitamin D. This study provides original information regarding mechanisms, in which vitamin D plays a key role in preventing tumor progression in human melanoma cells.