Human drug efflux transporter ABCC5 confers acquired resistance to pemetrexed in breast cancer.

Jihui ChenZhipeng WangShouhong GaoKejin WuFang BaiQiqiang ZhangHongyu WangQin YeFengjing XuHong SunYunshu LuYan Liu

Published in: Cancer cell international (2021)

Our results indicated that ABCC5 expression was associated with pemetrexed resistance in vitro and in vivo, and it may serve as a target or biomarker for the optimization of pemetrexed regimen in breast cancer treatment.

Keyphrases

small cell lung cancer
advanced non small cell lung cancer
endothelial cells
poor prognosis
induced pluripotent stem cells
pluripotent stem cells
emergency department
long non coding rna
adverse drug
childhood cancer