MET-Induced CD73 Restrains STING-Mediated Immunogenicity of EGFR-Mutant Lung Cancer.

Ryohei Yoshida Maria Saigí Tetsuo Tani Benjamin F Springer Hirofumi Shibata Shunsuke Kitajima Navin R Mahadevan Marco Campisi Jong Wook Kim Yoshihisa Kobayashi Tran C Thai Koji Haratani Yurie Yamamoto Shriram K Sundararaman Erik H Knelson Amir Vajdi Israel Cañadas Ravindra Uppaluri Cloud P Paweletz Juan J Miret Patrick H Lizotte Prafulla C Gokhale Pasi A Janne David A Barbie

Published in: Cancer research (2022)

MET amplification upregulates CD73 to suppress tumor cell STING induction and T-cell responsiveness in TKI-resistant, EGFR-mutated lung cancer, identifying a strategy to enhance immunogenicity and improve treatment.

Keyphrases

tyrosine kinase
epidermal growth factor receptor
small cell lung cancer
high glucose
single cell
advanced non small cell lung cancer
nk cells
diabetic rats
wild type
cell therapy
endothelial cells
oxidative stress
drug induced
stem cells
label free