MET-Induced CD73 Restrains STING-Mediated Immunogenicity of EGFR-Mutant Lung Cancer.
Ryohei YoshidaMaria SaigíTetsuo TaniBenjamin F SpringerHirofumi ShibataShunsuke KitajimaNavin R MahadevanMarco CampisiJong Wook KimYoshihisa KobayashiTran C ThaiKoji HarataniYurie YamamotoShriram K SundararamanErik H KnelsonAmir VajdiIsrael CañadasRavindra UppaluriCloud P PaweletzJuan J MiretPatrick H LizottePrafulla C GokhalePasi A JanneDavid A BarbiePublished in: Cancer research (2022)
MET amplification upregulates CD73 to suppress tumor cell STING induction and T-cell responsiveness in TKI-resistant, EGFR-mutated lung cancer, identifying a strategy to enhance immunogenicity and improve treatment.