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Caveolin gene expression predicts clinical outcomes for early-stage HER2-negative breast cancer treated with paclitaxel-based chemotherapy in the GeparSepto trial.

Terence M WilliamsAndreas SchneeweißChristian JackischChangxian ShenKarsten E WeberPeter Andreas FaschingCarsten DenkertJenny FurlanettoErnst HeinmöllerSabine SchmatlochThomas KarnChristopher W SzetoMarion T van MackelenberghValentina NekljudovaElmar StickelerPatrick Soon-ShiongChristian SchemThomas MairingerVolkmar MuellerFrederic MarméMichael UntchSibylle Loibl
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Our findings indicate high CAV1/2 expression is associated with worse DFS and OS in paclitaxel-treated patients. Conversely, in nab-paclitaxel-treated patients, high CAV1/2 expression is associated with increased pCR and no significant detriment to DFS or OS compared to low CAV1/2 expression.
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