Redirecting B7-H3.CAR T cells to Chemokines Expressed in Osteosarcoma Enhances Homing and Antitumor Activity in Preclinical Models.

Lindsey J Talbot Ashley Chabot Aaron B Ross Alexandra Beckett Phuong Nguyen Andrew M Fleming Peter J Chockley Heather S Sheppard Jian Wang Stephen Gottschalk Christopher DeRenzo

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Our patient-based pipeline identified targets for chemokine receptor modification of CAR T cells targeting OS. CXCR2 and CXCR6 expression enhanced homing and anti-OS activity of B7-H3.CAR T cells. These findings support clinical evaluation of CXCR-modified CAR T cells to improve adoptive cell therapy for OS patients.

Keyphrases

cell therapy
end stage renal disease
poor prognosis
cell migration
single cell
prognostic factors
case report
binding protein
stem cells
patient reported outcomes
drug delivery
cancer therapy
data analysis